Construction of chiral quaternary carbon centers by asymmetric alkylation of achiral lithium enolates mediated by chiral tetradentate ligands: Stoichiometric and catalytic approaches

被引：38

作者：

Yamashita, Y ^{[1
]}

Odashima, K ^{[1
]}

Koga, K ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 14期

关键词：

asymmetric synthesis; enantioselection; quaternization; catalysis;

D O I：

10.1016/S0040-4039(99)00299-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective asymmetric alkylation of achiral lithium enolates mediated by chiral tetradentate amine ligands is achieved to give chiral quaternary carbon centers. Turnover of a chiral tetradentate amine in the presence of an achiral bidentate amine during the reaction is also realized. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2803 / 2806

页数：4