Opinion - Are follicular dendritic cells really good for nothing?

被引：124

作者：

Kosco-Vilbois, MH

机构：

[1] NovImmune S.A., CH-1205 Geneva

来源：

NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nri1179

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.

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收藏

页码：764 / 769

页数：7

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