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Opinion - Are follicular dendritic cells really good for nothing?

被引：124
作者：
Kosco-Vilbois, MH
机构：
[1] NovImmune S.A., CH-1205 Geneva
来源：
NATURE REVIEWS IMMUNOLOGY | 2003年 / 3卷 / 09期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nri1179
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Follicular dendritic cells (FDCs), which reside in the primary B-cell follicles and germinal centres of lymphoid tissues, can sequester antigen in the form of immune complexes and are thought to be pivotal to the germinal-centre reaction and the maintenance of immunological memory. But, many recent studies question the importance of FDCs and their bound immune complexes in B-cell responses. This article asks whether we can truly rule out a requirement for these cells in host defence.
引用
收藏
页码：764 / 769
页数：7
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