Toward the creation of NMR databases in chiral solvents for assignments of relative and absolute stereochemistry: Proof of concept

被引：34

作者：

Kobayashi, Y ^{[1
]}

Hayashi, N ^{[1
]}

Tan, CH ^{[1
]}

Kishi, Y ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 14期

关键词：

D O I：

10.1021/ol010108z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An NMR database approach in a chiral solvent allows us to predict both relative and absolute stereochemistry of an unknown compound without degradation and/or derivatization, N,alpha -Dimethylbenzylamine (DMBA) is a suitable solvent for this purpose. Using the C.5-C.10 portion of oasomycin A, the feasibility and reliability of this approach is demonstrated.

引用

页码：2245 / 2248

页数：4

共 21 条

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