Autophagy and Aging

被引：1748

作者：

Rubinsztein, David C. ^{[1
]}

Marino, Guillermo ^{[2
,3
,4
]}

Kroemer, Guido ^{[2
,3
,5
,6
,7
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med Genet, Cambridge Inst Med Res, Cambridge CB2 0XY, England

[2] INSERM, U848, F-94805 Villejuif, France

[3] Inst Gustave Roussy, F-94805 Villejuif, France

[4] Univ Paris Sud, F-94805 Villejuif, France

[5] Ctr Rech Cordeliers, F-75006 Paris, France

[6] Hop Europeen Georges Pompidou, AP HP, F-75015 Paris, France

[7] Univ Paris 05, Fac Med, F-75006 Paris, France

来源：

CELL | 2011年 / 146卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

LIFE-SPAN EXTENSION; BETA-CELL MASS; CALORIC RESTRICTION; MEDIATED AUTOPHAGY; MAMMALIAN AUTOPHAGY; DIETARY RESTRICTION; PROTEIN-SYNTHESIS; LONGEVITY; DISEASE; STRESS;

D O I：

10.1016/j.cell.2011.07.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Genetic inhibition of autophagy induces degenerative changes in mammalian tissues that resemble those associated with aging, and normal and pathological aging are often associated with a reduced autophagic potential. Pharmacological or genetic manipulations that increase life span in model organisms often stimulate autophagy, and its inhibition compromises the longevity-promoting effects of caloric restriction, Sirtuin 1 activation, inhibition of insulin/insulin growth factor signaling, or the administration of rapamycin, resveratrol, or spermidine. Here, we discuss the probable cause and effect relationship between perturbed autophagy and aging, as well as possible molecular mechanisms that may mediate the anti-aging effects of autophagy.

引用

页码：682 / 695

页数：14

共 108 条

[41] Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration [J].

Komatsu, Masaaki ;

Wang, Qing Jun ;

Holstein, Gay R. ;

Friedrich, Victor L., Jr. ;

Iwata, Jun-ichi ;

Kominami, Eiki ;

Chait, Brian T. ;

Tanaka, Keiji ;

Yue, Zhenyu .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (36) :14489-14494

[42] Loss of autophagy in the central nervous system causes neurodegeneration in mice [J].

Komatsu, Masaaki ;

Waguri, Satoshi ;

Chiba, Tomoki ;

Murata, Shigeo ;

Iwata, Jun-ichi ;

Tanida, Isei ;

Ueno, Takashi ;

Koike, Masato ;

Uchiyama, Yasuo ;

Kominami, Eiki ;

Tanaka, Keiji .

NATURE, 2006, 441 (7095) :880-884

[43] The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1 [J].

Komatsu, Masaaki ;

Kurokawa, Hirofumi ;

Waguri, Satoshi ;

Taguchi, Keiko ;

Kobayashi, Akira ;

Ichimura, Yoshinobu ;

Sou, Yu-Shin ;

Ueno, Izumi ;

Sakamoto, Ayako ;

Tong, Kit I. ;

Kim, Mihee ;

Nishito, Yasumasa ;

Iemura, Shun-ichiro ;

Natsume, Tohru ;

Ueno, Takashi ;

Kominami, Eiki ;

Motohashi, Hozumi ;

Tanaka, Keiji ;

Yamamoto, Masayuki .

NATURE CELL BIOLOGY, 2010, 12 (03) :213-U17

[44] Lysosomal positioning coordinates cellular nutrient responses [J].

Korolchuk, Viktor I. ;

Saiki, Shinji ;

Lichtenberg, Maike ;

Siddiqi, Farah H. ;

Roberts, Esteban A. ;

Imarisio, Sara ;

Jahreiss, Luca ;

Sarkar, Sovan ;

Futter, Marie ;

Menzies, Fiona M. ;

O'Kane, Cahir J. ;

Deretic, Vojo ;

Rubinsztein, David C. .

NATURE CELL BIOLOGY, 2011, 13 (04) :453-U242

[45] Autophagy Inhibition Compromises Degradation of Ubiquitin-Proteasome Pathway Substrates [J].

Korolchuk, Viktor I. ;

Mansilla, Alicia ;

Menzies, Fiona M. ;

Rubinsztein, David C. .

MOLECULAR CELL, 2009, 33 (04) :517-527

[46] Mitochondrial membrane permeabilization in cell death [J].

Kroemer, Guido ;

Galluzzi, Lorenzo ;

Brenner, Catherine .

PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :99-163

[47] Autophagic cell death: the story of a misnomer [J].

Kroemer, Guido ;

Levine, Beth .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2008, 9 (12) :1004-1010

[48] Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney [J].

Kume, Shinji ;

Uzu, Takashi ;

Horiike, Kihachiro ;

Chin-Kanasaki, Masami ;

Isshiki, Keiji ;

Araki, Shin-ichi ;

Sugimoto, Toshiro ;

Haneda, Masakazu ;

Kashiwagi, Atsunori ;

Koya, Daisuke .

JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (04) :1043-1055

[49] Hormesis, aging and longevity [J].

Le Bourg, Eric .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2009, 1790 (10) :1030-1039

[50] A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy [J].

Lee, In Hye ;

Cao, Liu ;

Mostoslavsky, Raul ;

Lombard, David B. ;

Liu, Jie ;

Bruns, Nicholas E. ;

Tsokos, Maria ;

Alt, Frederick W. ;

Finkel, Toren .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (09) :3374-3379

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