Chemistry of puffer fish toxin

被引：85

作者：

Yotsu-Yamashita, M ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

JOURNAL OF TOXICOLOGY-TOXIN REVIEWS | 2001年 / 20卷 / 01期

关键词：

D O I：

10.1081/TXR-100102536

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Tetrodotoxin (TTX) is well known as the puffer fish toxin. Naturally occurring analogs of TTX have been isolated from puffer fish, newts and frogs, and their structures have been determined by spectroscopic methods. Additionally, TTX analogs have been prepared by chemical modification to investigate its binding site on sodium channels and the structure-activity relationship of TTX. In this article, the NMR data of TTX analogs are listed, and the chemical modification methods for preparation of TTX probes are summarized.

引用

页码：51 / 66

页数：16

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