Plasticity of specialized metabolism as mediated by dynamic metabolons

被引：95

作者：

Laursen, Tomas ^{[1
,2
]}

Moller, Birger Lindberg ^{[1
,2
,3
]}

Bassard, Jean-Etienne ^{[1
,2
]}

机构：

[1] Univ Copenhagen, VILLUM Res Ctr Plant Plast, Ctr Synthet Biol bioSYNergy, 40 Thorvaldsensvej, DK-1871 Frederiksberg C, Denmark

[2] Univ Copenhagen, Plant Biochem Lab, Dept Plant & Environm Sci, 40 Thorvaldsensvej, DK-1871 Frederiksberg C, Denmark

[3] Carlsberg Lab, 10 Gamle Carlsberg Vej, DK-1799 Copenhagen V, Denmark

来源：

TRENDS IN PLANT SCIENCE | 2015年 / 20卷 / 01期

关键词：

CYANOGENIC GLUCOSIDE DHURRIN; DEEP EUTECTIC SOLVENTS; P-HYDROXYPHENYLACETALDEHYDE OXIME; PHENYLALANINE AMMONIA-LYASE; HUMAN CYTOCHROME P4502C9; LIVING PLANT-CELLS; SORGHUM-BICOLOR; MEMBRANE-PROTEIN; ELECTRON-TRANSFER; ARABIDOPSIS CATALYZES;

D O I：

10.1016/j.tplants.2014.11.002

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

The formation of specialized metabolites enables plants to respond to biotic and abiotic stresses, but requires the sequential action of multiple enzymes. To facilitate swift production and to avoid leakage of potentially toxic and labile intermediates, many of the biosynthetic pathways are thought to organize in multienzyme clusters termed metabolons. Dynamic assembly and disassembly enable the plant to rapidly switch the product profile and thereby prioritize its resources. The lifetime of metabolons is largely unknown mainly due to technological limitations. This review focuses on the factors that facilitate and stimulate the dynamic assembly of metabolons, including microenvironments, noncatalytic proteins, and allosteric regulation. Understanding how plants organize carbon fluxes within their metabolic grids would enable targeted bioengineering of high-value specialized metabolites.

引用

页码：20 / 32

页数：13

共 185 条

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Deep eutectic solvents formed between choline chloride and carboxylic acids: Versatile alternatives to ionic liquids [J].