IL-10 family of cytokines

被引：326

作者：

Sabat, Robert ^{[1
,2
,3
]}

机构：

[1] Univ Hosp Charite, Interdisciplinary Grp Mol Immunopathol, Mol Immunopathol Interdisciplinary Dept, D-10117 Berlin, Germany

[2] Univ Hosp Charite, Dept Dermatol, Psoriasis Res & Treatment Ctr, D-10117 Berlin, Germany

[3] Univ Hosp Charite, Res Ctr Immunosci, D-10117 Berlin, Germany

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2010年 / 21卷 / 05期

关键词：

Psoriasis; Inflammatory bowel disease; RORgammaT; AHR; Interferon; NF-KAPPA-B; CRYSTAL-STRUCTURE; T-CELL; RHEUMATOID-ARTHRITIS; INTERFERON-GAMMA; EPITHELIAL-CELLS; POTENTIAL ROLE; CUTTING EDGE; MOUSE MODEL; INTERLEUKIN-10; REVEALS;

D O I：

10.1016/j.cytogfr.2010.11.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

LtdIn 2001, six immune mediators (IL-10, IL-19, IL-20, IL-22, IL-24, and IL-26) were grouped into the so-called IL-10 family of cytokines based on their similarities with respect to the structure and location of their encoding genes, their primary and secondary protein structures, and the receptor complexes used. Surprisingly, despite all these similarities, IL-10 family members possess different biological functions. The currently known facts regarding the biological effects of these six immune mediators give the impression that at least IL-10, IL-20, and IL-22 play an important role in the pathogenesis of some chronic inflammatory diseases. This review provides an overview of the most important and common aspects of the IL-10 family members. (C) 2010 Elsevier Ltd. All rights reserved.

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收藏

页码：315 / 324

页数：10

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