Carbohydrate sulfonyl chlorides for simple, convenient access to glycoconjugates

被引：50

作者：

Kvaerno, L ^{[1
]}

Werder, M ^{[1
]}

Hauser, H ^{[1
]}

Carreira, EM ^{[1
]}

机构：

[1] ETH Honggerberg, Organ Chem Lab, HCI H335, CH-8093 Zurich, Switzerland

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 06期

关键词：

D O I：

10.1021/ol0502127

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The use of carbohydrate sulfonyl chlorides is introduced as a new, facile glycoconjugation method which could find broad applications. We demonstrate the approach by synthesizing a number of glycosylated cholesterol absorption inhibitors which display high inhibitory efficacies in our recently established in vitro assay. Furthermore, we highlight an advantage of the electron-withdrawing nature of the suffonyl linkage which allowed the synthesis of otherwise unstable azetidine conjugates.

引用

页码：1145 / 1148

页数：4

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