Genetics of insulin-dependent diabetes mellitus

被引：10

作者：

Julier, C

Hashimoto, L

Lathrop, GM

机构：

[1] Wellcome Trust Ctr. for Hum. Genet., University of Oxford, Oxford

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1996年 / 6卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0959-437X(96)80014-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies that have focused on the detection of non-MHC susceptibility loci in insulin-dependent diabetes mellitus are reviewed. It has been confirmed that the region on human chromosome lip contains such a susceptibility locus and recent research has attempted to identify the causative DNA variants and their functional role in disease.

引用

页码：354 / 360

页数：7

共 51 条

[1] INSULIN GENE REGION-ENCODED SUSCEPTIBILITY TO TYPE-1 DIABETES IS NOT RESTRICTED TO HLA-DR4-POSITIVE INDIVIDUALS [J].

BAIN, SC ;

PRINS, JB ;

HEARNE, CM ;

RODRIGUES, NR ;

ROWE, BR ;

PRITCHARD, LE ;

RITCHIE, RJ ;

HALL, JRS ;

UNDLIEN, DE ;

RONNINGEN, KS ;

DUNGER, DB ;

BARNETT, AH ;

TODD, JA .

NATURE GENETICS, 1992, 2 (03) :212-215

[2] A POLYMORPHIC LOCUS NEAR THE HUMAN INSULIN GENE IS ASSOCIATED WITH INSULIN-DEPENDENT DIABETES-MELLITUS [J].

BELL, GI ;

HORITA, S ;

KARAM, JH .

DIABETES, 1984, 33 (02) :176-183

[3] POLYMORPHIC DNA REGION ADJACENT TO THE 5'-END OF THE HUMAN INSULIN GENE [J].

BELL, GI ;

KARAM, JH ;

RUTTER, WJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (09) :5759-5763

[4] SUSCEPTIBILITY TO HUMAN TYPE-1 DIABETES AT IDDM2 IS DETERMINED BY TANDEM REPEAT VARIATION AT THE INSULIN GENE MINISATELLITE LOCUS [J].

BENNETT, ST ;

LUCASSEN, AM ;

GOUGH, SCL ;

POWELL, EE ;

UNDLIEN, DE ;

PRITCHARD, LE ;

MERRIMAN, ME ;

KAWAGUCHI, Y ;

DRONSFIELD, MJ ;

POCIOT, F ;

NERUP, J ;

BOUZEKRI, N ;

CAMBONTHOMSEN, A ;

RONNINGEN, KS ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (03) :284-292

[5]

BUI MM, 1993, DIABETES, V42, pA63

[6] LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33 [J].

COPEMAN, JB ;

CUCCA, F ;

HEARNE, CM ;

CORNALL, RJ ;

REED, PW ;

RONNINGEN, KS ;

UNDLIEN, DE ;

NISTICO, L ;

BUZZETTI, R ;

TOSI, R ;

POCIOT, F ;

NERUP, J ;

CORNELIS, F ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE GENETICS, 1995, 9 (01) :80-85

[7]

CORDELL HJ, 1995, AM J HUM GENET, V57, P920

[8] MULTIFACTORIAL INHERITANCE IN TYPE-1 DIABETES [J].

CORDELL, HJ ;

TODD, JA .

TRENDS IN GENETICS, 1995, 11 (12) :499-504

[9] A GENOME-WIDE SEARCH FOR HUMAN TYPE-1 DIABETES SUSCEPTIBILITY GENES [J].

DAVIES, JL ;

KAWAGUCHI, Y ;

BENNETT, ST ;

COPEMAN, JB ;

CORDELL, HJ ;

PRITCHARD, LE ;

REED, PW ;

GOUGH, SCL ;

JENKINS, SC ;

PALMER, SM ;

BALFOUR, KM ;

ROWE, BR ;

FARRALL, M ;

BARNETT, AH ;

BAIN, SC ;

TODD, JA .

NATURE, 1994, 371 (6493) :130-136

[10] EXCESS OF MATERNAL HLA-DR3 ANTIGENS IN HLA DR3,4 POSITIVE TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS [J].

DESCHAMPS, I ;

HORS, J ;

CLERGETDARPOUX, F ;

GARDAIS, E ;

ROBERT, JJ ;

MARCELLIBERGE, A ;

LESTRADET, H ;

DAUSSET, J .

DIABETOLOGIA, 1990, 33 (07) :425-430

← 1 2 3 4 5 6 →