LINKAGE DISEQUILIBRIUM MAPPING OF A TYPE-1 DIABETES SUSCEPTIBILITY GENE (IDDM7) TO CHROMOSOME 2Q31-Q33

被引：224

作者：

COPEMAN, JB

CUCCA, F

HEARNE, CM

CORNALL, RJ

REED, PW

RONNINGEN, KS

UNDLIEN, DE

NISTICO, L

BUZZETTI, R

TOSI, R

POCIOT, F

NERUP, J

CORNELIS, F

BARNETT, AH

BAIN, SC

TODD, JA

机构：

[1] UNIV OXFORD,WELLCOME TRUST CTR HUMAN GENET,NUFFIELD DEPT SURG,OXFORD OX3 7BN,ENGLAND

[2] NATL HOSP NORWAY,INST TRANSPLANTAT IMMUNOL,N-0027 OSLO,NORWAY

[3] UNIV ROMA LA SAPIENZA,IST CLIN MED 2,ROME,ITALY

[4] CNR,IST BIOL CELLULARE,I-00137 ROME,ITALY

[5] STENO DIABET CTR,DK-2820 GENTOFTE,DENMARK

[6] HOP ST LOUIS,INSERM,U358,F-75010 PARIS,FRANCE

[7] UNIV BIRMINGHAM,BIRMINGHAM HEARTLANDS HOSP,DEPT MED DIABET ENDOCRINOL,BIRMINGHAM B9 5SS,W MIDLANDS,ENGLAND

来源：

NATURE GENETICS | 1995年 / 9卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ng0195-80

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The role of human chromosome 2 in type 1 diabetes was evaluated by analysing linkage and linkage disequilibrium at 21 microsatellite marker loci, using 348 affected sibpair families and 107 simplex families. The microsatellite D2S152 was linked to, and associated with, disease in families from three different populations. Our evidence localizes a new diabetes susceptibility gene, IDDM7, to within two centiMorgans of D2S152. This places it in a region of chromosome 2q that shows conserved synteny with the region of mouse chromosome 1 containing the murine type 1 diabetes gene, Idd5. These results demonstrate the utility of polymorphic microsatellites for linkage disequilibrium mapping of genes for complex diseases.

引用

页码：80 / 85

页数：6

共 57 条

[1] CONSTRUCTION AND CHARACTERIZATION OF A YEAST ARTIFICIAL CHROMOSOME LIBRARY CONTAINING 7 HAPLOID HUMAN GENOME EQUIVALENTS [J].