The role of oxidative stress in the genesis of heart disease

被引:239
作者
Singal, PK
Khaper, N
Palace, V
Kumar, D
机构
[1] St Boniface Gen Hosp, Res Ctr, Inst Cardiovasc Sci, Winnipeg, MB R2H 2A6, Canada
[2] Univ Manitoba, Fac Med, Dept Physiol, Winnipeg, MB, Canada
基金
英国医学研究理事会;
关键词
free radicals; antioxidants; heart failure;
D O I
10.1016/S0008-6363(98)00244-2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although researchers in radiation and cancer biology have known about the existence of free radicals and their potential role in pathobiology for several decades, cardiac biologists only began to take notice of these noxious species in the 1970s. Exponential growth of free radical research occurred after die discovery of superoxide dismutase in 1969. This antioxidant enzyme is responsible for the dismutation of superoxide radical - a free radical chain initiator. A fine balance between free radicals and a variety of endogenous antioxidants is believed to exist. Any disturbance in this equilibrium in favour of free radicals causes an increase in oxidative stress and initiates subcellular changes leading to cardiomyopathy and heart failure. Our knowledge about the role of free radicals in the pathogenesis of cardiac dysfunction is fast approaching the point where newer therapies employing antioxidants are in sight. (C) 1998 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:426 / 432
页数:7
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