Decreased susceptibility to pentylenetetrazol-induced seizures after low-frequency transcranial magnetic stimulation in rats

被引：62

作者：

Akamatsu, N

Fueta, Y

Endo, Y

Matsunaga, K

Uozumi, T

Tsuji, S

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Neurol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

[2] Univ Occupat & Environm Hlth, Sch Hlth Sci, Dept Med Technol, Kitakyushu, Fukuoka 8078555, Japan

[3] Univ Occupat & Environm Hlth, Sch Med, Dept Physiol, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan

来源：

NEUROSCIENCE LETTERS | 2001年 / 310卷 / 2-3期

关键词：

transcranial magnetic stimulation; epilepsy; pentylenetetrazol; treatment;

D O I：

10.1016/S0304-3940(01)02116-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the effects of I ow-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of status epilepticus of pentylenetetrazol-induced convulsions. These findings indicate that low-frequency rTMS affects the neural excitability, in the direction of anticonvulsive, and therefore, suggest the possibility of therapeutic use of rTMS in epilepsy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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收藏

页码：153 / 156

页数：4

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