Novel roles for Nogo receptor in inflammation and disease

被引：59

作者：

David, Samuel ^{[1
]}

Fry, Elizabeth J. ^{[1
]}

Lopez-Vales, Ruben ^{[1
]}

机构：

[1] McGill Univ, Ctr Hlth, Res Inst, Ctr Res Neurosci, Montreal, PQ H3G 1A4, Canada

来源：

TRENDS IN NEUROSCIENCES | 2008年 / 31卷 / 05期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1016/j.tins.2008.02.002

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The Nogo receptor (NgR), which was identified as a common receptor for three axon growth inhibitors associated with myelin, has been extensively characterized for its role in triggering growth cone collapse and arresting neurite/axon growth. Recent studies indicate that NgR is also expressed in nonneuronal cells and modulates macrophage responses during inflammation after peripheral nerve injury. In this article, we discuss the possibility that NgR might have wider effects on inflammation in a variety of neurological conditions ranging from central nervous system trauma to diseases such as multiple sclerosis or Alzheimer's disease.

引用

收藏

页码：221 / 226

页数：6

相关论文

共 48 条

[1]

Aepfelbacher M, 1996, J IMMUNOL, V157, P5070

[2] ADAMs family members as amyloid precursor protein α-secretases [J].

Allinson, TMJ ;

Parkin, ET ;

Turner, AJ ;

Hooper, NM .

JOURNAL OF NEUROSCIENCE RESEARCH, 2003, 74 (03) :342-352

[3] Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease [J].

Bard, F ;

Cannon, C ;

Barbour, R ;

Burke, RL ;

Games, D ;

Grajeda, H ;

Guido, T ;

Hu, K ;

Huang, JP ;

Johnson-Wood, K ;

Khan, K ;

Kholodenko, D ;

Lee, M ;

Lieberburg, I ;

Motter, R ;

Nguyen, M ;

Soriano, F ;

Vasquez, N ;

Weiss, K ;

Welch, B ;

Seubert, P ;

Schenk, D ;

Yednock, T .

NATURE MEDICINE, 2000, 6 (08) :916-919

[4] Sequential loss of myelin proteins during Wallerian degeneration in the human spinal cord [J].

Buss, A ;

Pech, K ;

Merkler, D ;

Kakulas, BA ;

Martin, D ;

Schoenen, J ;

Noth, J ;

Schwab, ME ;

Brook, GA .

BRAIN, 2005, 128 :356-364

[5] Sequential loss of myelin proteins during Wallerian degeneration in the rat spinal cord [J].

Buss, A ;

Schwab, ME .

GLIA, 2003, 42 (04) :424-432

[6] Nogo-A-deficient mice reveal strain-dependent differences in axonal regeneration [J].

Dimou, Leda ;

Schnell, Lisa ;

Montani, Laura ;

Duncan, Carri ;

Simonen, Marjo ;

Schneider, Regula ;

Liebscher, Thomas ;

Gullo, Miriam ;

Schwab, Martin E. .

JOURNAL OF NEUROSCIENCE, 2006, 26 (21) :5591-5603

[7] Myelin-associated glycoprotein interacts with the Nogo66 receptor to inhibit neurite outgrowth [J].

Domeniconi, M ;

Cao, ZU ;

Spencer, T ;

Sivasankaran, R ;

Wang, KC ;

Nikulina, E ;

Kimura, N ;

Cai, H ;

Deng, KW ;

Gao, Y ;

He, ZG ;

Filbin, MT .

NEURON, 2002, 35 (02) :283-290

[8] Rho activation patterns after spinal cord injury and the role of activated Rho in apoptosis in the central nervous system [J].

Dubreuil, CI ;

Winton, MJ ;

McKerracher, L .

JOURNAL OF CELL BIOLOGY, 2003, 162 (02) :233-243

[9] The cellular inflammatory response in human spinal cords after injury [J].

Fleming, Jennifer C. ;

Norenberg, Michael D. ;

Ramsay, David A. ;

Dekaban, Gregory A. ;

Marcillo, Alexander E. ;

Saenz, Alvaro D. ;

Pasquale-Styles, Melissa ;

Dietrich, W. Dalton ;

Weaver, Lynne C. .

BRAIN, 2006, 129 :3249-3269

[10] Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration [J].

Fournier, AE ;

GrandPre, T ;

Strittmatter, SM .

NATURE, 2001, 409 (6818) :341-346

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