Physical Exercise Improves Glycemic and Inflammatory Profile and Attenuates Progression of Periodontitis in Diabetic Rats (HFD/STZ)

被引:38
作者
Andrade, Eric Francelino [1 ,2 ]
Silva, Viviam de Oliveira [1 ,3 ]
de Moura, Natalia Oliveira [1 ]
Foureaux, Renata de Carvalho [1 ]
Orlando, Debora Ribeiro [1 ,2 ]
de Moura, Rodrigo Ferreira [4 ]
Pereira, Luciano Jose [1 ,4 ]
机构
[1] Univ Fed Lavras, Dept Vet Med, BR-37200000 Lavras, MG, Brazil
[2] Fed Univ Jequitinhonha & Mucuri Valleys, Inst Agr Sci, BR-38610000 Unai, MG, Brazil
[3] Ctr Univ Atenas, Dept Res & Sci Iniciat, BR-38600000 Paracatu, MG, Brazil
[4] Univ Fed Lavras, Dept Hlth Sci, BR-37200000 Lavras, MG, Brazil
关键词
chronic periodontitis; physical training; metabolic disorder; alveolar bone loss; ALVEOLAR BONE LOSS; HIGH-FAT DIET; INSULIN-RESISTANCE; DISEASE; SUPPLEMENTATION; MECHANISMS; MELLITUS; THERAPY; MODELS; TYPE-1;
D O I
10.3390/nu10111702
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 [营养与食品卫生学];
摘要
The authors aimed to evaluate the effects of physical exercise on the metabolism and progression of periodontal disease (PD), induced by ligature in diabetic rats induced by high fat diet and streptozotocin (HFD/STZ). Diabetes Mellitus (DM) was induced by four weeks of a hyperlipidic diet associated with a single low-dose of streptozotocin (35 mg/kg/animal). The exercise groups swam for 60 min/day for eight weeks (five times/week). In the last two weeks of exercise, a ligature was placed around the right and left mandibular first molars. The authors determined alveolar bone loss by morphometry. Blood biochemical profile and serum levels of IL-10 and TNF-alpha were evaluated by colorimetric and enzyme-linked immunosorbent assays (ELISA), respectively. The diabetic animals subjected to exercise showed decreased alveolar bone loss, lower glycemia, triacylglycerols and glycosylated hemoglobin levels than the controls. Total cholesterol and its fractions (High density lipoprotein-HDL-c, Low density lipoprotein-LDL-c and Very low density lipoprotein-VLDL-c) remained similar among the groups. Animals with PD showed higher levels of TNF-alpha and lower levels of IL-10, when compared to animals without PD. In diabetic animals with PD, physical exercise decreased TNF-alpha levels and increased IL-10 levels as well as the IL10/TNF-alpha ratio. In conclusion, eight weeks of physical exercise improved glycemic control and systemic inflammatory profile, and attenuated alveolar bone loss in rats with DM and PD.
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页数:12
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