AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status

被引：17

作者：

Falvella, F. S. ^{[1
]}

Spinola, M. ^{[1
]}

Pignatiello, C. ^{[1
]}

Noci, S. ^{[1
]}

Conti, B. ^{[2
]}

Pastorino, U. ^{[2
]}

Carbone, A. ^{[3
]}

Dragani, T. A. ^{[1
]}

机构：

[1] Ist Nazl Tumori, Fdn IRCCS, Dept Expt Oncol & Labs, I-20133 Milan, Italy

[2] Ist Nazl Tumori, Fdn IRCCS, Dept Thorac Surg, I-20133 Milan, Italy

[3] Ist Nazl Tumori, Fdn IRCCS, Dept Pathol, I-20133 Milan, Italy

来源：

ONCOGENE | 2008年 / 27卷 / 11期

关键词：

genetic susceptibility; complex diseases; gene expression; inherited predisposition; lung neoplasms; microarray;

D O I：

10.1038/sj.onc.1210775

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Evidence in animal models has suggested an association between susceptibility to lung tumorigenesis and geneexpression profiles in normal lung. Here, we compared RNA pools from normal lung tissue of lung adenocarcinoma patients (cases) or non-lung cancer patients (controls) by hybridization of whole-human genome expression arrays. Principal component analysis identified a gene-expression signature of 85 genes that distinguishes cases from controls as well as smokers from nonsmokers. Elevated mRNA levels of one of these genes, AZGP1, were significantly associated with disease status. These results support the hypothesis that differences in the gene-expression levels of the normal tissue may be predictive of genetic predisposition to lung cancer in humans.

引用

页码：1650 / 1656

页数：7

共 19 条

[1] A major lung cancer susceptibility locus maps to chromosome 6q23-25 [J].

Bailey-Wilson, JE ;

Amos, CI ;

Pinney, SM ;

Petersen, GM ;

de Andrade, M ;

Wiest, JS ;

Fain, P ;

Schwartz, AG ;

You, M ;

Franklin, W ;

Klein, C ;

Gazdar, A ;

Rothschild, H ;

Mandal, D ;

Coons, T ;

Slusser, J ;

Lee, J ;

Gaba, C ;

Kupert, E ;

Perez, A ;

Zhou, X ;

Zeng, D ;

Liu, Q ;

Zhang, Q ;

Seminara, D ;

Minna, J ;

Anderson, MW .

AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (03) :460-474

[2] Zinc-α2-glycoprotein, a lipid mobilizing factor, is expressed in adipocytes and is up-regulated in mice with cancer cachexia [J].

Bing, C ;

Bao, Y ;

Jenkins, J ;

Sanders, P ;

Manieri, M ;

Cinti, S ;

Tisdale, MJ ;

Trayhurn, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (08) :2500-2505

[3] FUNCTIONAL-SIGNIFICANCE OF DIFFERENT HUMAN CYP1A1 GENOTYPES [J].

CROFTS, F ;

TAIOLI, E ;

TRACHMAN, J ;

COSMA, GN ;

CURRIE, D ;

TONIOLO, P ;

GARTE, SJ .

CARCINOGENESIS, 1994, 15 (12) :2961-2963

[4]

Dragani TA, 2003, CANCER RES, V63, P3011

[5] Stearoyl-CoA desaturase 1 (Scd1) gene overexpression is associated with genetic predisposition to hepatocarcinogenesis in mice and rats [J].

Falvella, FS ;

Pascale, RM ;

Gariboldi, M ;

Manenti, G ;

De Miglio, MR ;

Simile, MM ;

Dragani, TA ;

Feo, F .

CARCINOGENESIS, 2002, 23 (11) :1933-1936

[6] Differential gene expression profiles in colon epithelium of two rat strains with distinct susceptibility to colon carcinogenesis after exposure to PhIP in combination with dietary high fat [J].

Fujiwara, K ;

Ochiai, M ;

Ubagai, T ;

Ohki, M ;

Ohta, T ;

Nagao, M ;

Sugimura, T ;

Nakagama, H .

CANCER SCIENCE, 2003, 94 (08) :672-678

[7] Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice [J].

Gariboldi, M ;

Spinola, M ;

Milani, S ;

Pignatiello, C ;

Kadota, K ;

Bono, H ;

Hayashizaki, Y ;

Dragani, TA ;

Okazaki, Y .

CARCINOGENESIS, 2003, 24 (11) :1819-1826

[8] Modification of gene expression of the small airway epithelium in response to cigarette smoking [J].

Harvey, Ben-Gary ;

Heguy, Adriana ;

Leopold, Philip L. ;

Carolan, Brendan J. ;

Ferris, Barbara ;

Crystal, Ronald G. .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2007, 85 (01) :39-53

[9] Zinc-alpha2-glycoprotein expression as a predictor of metastatic prostate cancer following radical prostatectomy [J].

Henshall, Susan M. ;

Horvath, Lisa G. ;

Quinn, David I. ;

Eggleton, Sarah A. ;

Grygiel, John J. ;

Stricker, Phillip D. ;

Biankin, Andrew V. ;

Kench, James G. ;

Sutherland, Robert L. .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (19) :1420-1424

[10] Cancer - Nature, nurture, or both [J].

Hoover, RN .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (02) :135-136

← 1 2 →