Stereoselective reduction of alkyl 3-oxobutanoate by carbonyl reductase from Candida magnoliae

被引：71

作者：

Yasohara, Y

Kizaki, N

Hasegawa, J

Wada, M

Kataoka, M

Shimizu, S

机构：

[1] Kaneka Corp, Fine Chem Res Labs, Takasago, Hyogo 6768688, Japan

[2] Fukui Prefectural Chem, Dept Biosci, Fukui 9101195, Japan

[3] Kyoto Univ, Grad Sch Agr, Div Appl Life Sci, Sakyo Ku, Kyoto 6068502, Japan

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(01)00279-8

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselective reduction of alkyl 3-oxobutanoates by carbonyl reductase (Sl) from Candida magnoliae was investigated. S1 reduced alkyl 4-halo-3-oxobutanoates to the corresponding enantiomerically pure (S)-3-hydroxy esters. Escherichia coli HB101 transformant co-overproducing the S1 and glucose dehydrogenase from Bacillus megaterium, produced optically pure alkyl 4-substituted-3-hydroxybutanoates in a two-phase water/organic solvent system. (C) 2001 Elsevier Science Ltd. All rights reserved.

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页码：1713 / 1718

页数：6

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