Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by fungi

被引：6

作者：

Iwamoto, K

Kuramoto, T

Izumi, M

Kirihata, M

Dohmaru, T

Yoshizako, F

机构：

[1] Univ Osaka Prefecture, Adv Sci & Technol Res Inst, Sakai, Osaka 5998570, Japan

[2] Osaka Univ, Grad Sch Sci, Dept Chem, Toyonaka, Osaka 5600043, Japan

[3] Univ Osaka Prefecture, Coll Agr, Dept Appl Biochem, Sakai, Osaka 5998531, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2000年 / 64卷 / 01期

关键词：

Penicillium purpurogenum; asymmetric reduction; ethyl; 2-methyl; 3-oxobutanoate; (2S; 3S)-ethyl; 3-hydroxybutanoate; 3R)-ethyl;

D O I：

10.1271/bbb.64.194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven fungi, which are found to reduce ethyl 3-oxobutanoate in high yields, were tested for their reducing ability for ethyl 2-methyl 3-oxobutanoate. We obtained some interesting findings. In particular, Penicillium purpurogenum reduced ethyl 2-methyl 3-oxobutanoate to the corresponding alcohols with the diastereomer (anti/syn) ratio of 93/7 with the enantiomeric excess of anti-(2S,3S)- and syn-(2S,3R)-hydroxy esters of 90 and >99 ee%, respectively.

引用

页码：194 / 197

页数：4

共 17 条

[1]

Bingfeng Pan, 1995, Enzyme and Microbial Technology, V17, P853, DOI 10.1016/0141-0229(95)00004-O

[2] DIASTEREOSELECTIVE AND ENANTIOSELECTIVE MICROBIOLOGICAL REDUCTION OF 2-METHYL 3-OXOALKANOATES [J].