ATHEROSCLEROSIS: A CLASSIC INFLAMMATORY DISEASE

被引：116

作者：

Anogeianaki, A. ^{[1
]}

Angelucci, D. ^{[2
]}

Cianchetti, E. ^{[3
]}

D'Alessandro, M. ^{[4
]}

Maccauro, G. ^{[5
]}

Saggini, A. ^{[6
]}

Salini, V. ^{[7
]}

Caraffa, A. ^{[8
]}

Tete, S. ^{[9
]}

Conti, F. ^{[10
]}

Tripodi, D. ^{[9
]}

Shaik-Dasthagirisaheb, Y. B. ^{[11
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Physiol, Fac Med, Sch Med, GR-54006 Thessaloniki, Greece

[2] Univ G dAnnunzio, AnatomoPathol Div, Chieti, Italy

[3] Ortona Hosp, Div Senol, Ortona, Italy

[4] Santo Spirito Hosp, Radiol Div, Pescara, Italy

[5] Univ Cattolica Sacro Cuore, Dept Orthopaed, Rome, Italy

[6] Univ Roma Tor Vergata, Dept Dermatol, Rome, Italy

[7] Univ G dAnnunzio, Orthopaed Div, Chieti, Italy

[8] Univ Perugia, Orthopaed Div, I-06100 Perugia, Italy

[9] Univ G dAnnunzio, Dept Oral Nano & Biotechnol, Chieti, Italy

[10] Santo Spirito Hosp, Dept Gyneacol, Pescara, Italy

[11] Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2011年 / 24卷 / 04期

关键词：

atherosclerosis; inflammation; cholesterol; phospholipid; ASYMPTOMATIC CAROTID ATHEROSCLEROSIS; LEUKOCYTE ADHESION MOLECULE; BLOOD MONONUCLEAR-CELLS; E-DEFICIENT MICE; ALLERGIC RHINITIS; IN-VITRO; SUBJECTIVE ASSESSMENT; NEUROBLASTOMA-CELLS; HEALTHY-VOLUNTEERS; ENDOTHELIAL-CELLS;

D O I：

10.1177/039463201102400401

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Atherosclerosis is an inflammatory disease due to a diet high in saturated fat, hypercholesterolemia, obesity, hypoglycemia, etc. mainly mediated by the infiltration of macrophage and T cells into the vascular wall. Once the endothelial is damaged monocytes penetrate the tissue and are transformed in scavenger cells. Upon stimulation of Th1 cells, a group of cytokines is released and contributes to the inflammatory response of atherosclerotic tissue. When macrophages proliferate they amplify inflammatory response through the secretion of growth factors and cytokines such as TNF and IL-1. In addition, chemokines such as RANTES and other C-C chemokines are generated, and matrix metalloprotinease 9 (MMP-9) are produced by activated monocytes. However, the immune system in atherosclerosis still remains unclear. Here, in this study we revisited the inter-relationship between atherosclerosis and inflammation.

引用

页码：817 / 825

页数：9

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