NMR study of the sequence-specific binding of the Delta-tris(ethylenediamine)cobalt(III) cation with d(TCGGGATCCCGA)(2)

被引：18

作者：

Fry, JV ^{[1
]}

Collins, JG ^{[1
]}

机构：

[1] UNIV COLL NEW S WALES, SCH CHEM, AUSTRALIAN DEF FORCE ACAD, CANBERRA, ACT 2600, AUSTRALIA

来源：

INORGANIC CHEMISTRY | 1997年 / 36卷 / 13期

关键词：

D O I：

10.1021/ic960937u

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

H-1 NMR spectroscopy was used to study the binding of Delta-Co(en)(3)(3+) to the dodecanucleotide d(TCGGG-GATCCCGA)(2). Intermolecular NOE cross peaks between the metal complex methylene protons and the dodecanucleotide unambiguously establish that Delta-Co(en)(3)(3+) selectively binds at GG sequences in the major groove. The NMR experiments indicated that the dodecanucleotide maintains a B-type DNA conformation upon metal complex binding.

引用

页码：2919 / +

页数：1

共 26 条

[1] TRIS(PHENANTHROLINE)RUTHENIUM(II) - STEREOSELECTIVITY IN BINDING TO DNA [J].

BARTON, JK ;

DANISHEFSKY, AT ;

GOLDBERG, JM .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (07) :2172-2176

[2] BINDING OF DELTA-[RU(PHEN)(3)](2+) AND LAMBDA-[RU(PHEN)(3)](2+) TO [D(CGCGATCGCG)](2) STUDIED BY NMR [J].

ERIKSSON, M ;

LEIJON, M ;

HIORT, C ;

NORDEN, B ;

GRASLUND, A .

BIOCHEMISTRY, 1994, 33 (17) :5031-5040

[3] TWO-DIMENSIONAL PROTON NUCLEAR MAGNETIC-RESONANCE INVESTIGATION OF THE SYNTHETIC DEOXYRIBONUCLEIC-ACID DECAMER D(ATATCGATAT)2 [J].

FEIGON, J ;

LEUPIN, W ;

DENNY, WA ;

KEARNS, DR .

BIOCHEMISTRY, 1983, 22 (25) :5943-5951

[4] THE BINDING OF MANGANESE(II) AND ZINC(II) TO THE SYNTHETIC OLIGONUCLEOTIDE D(C-G-C-G-A-A-T-T-C-G-C-G)2 - A H-1-NMR STUDY [J].

FROYSTEIN, NA ;

SLETTEN, E .

ACTA CHEMICA SCANDINAVICA, 1991, 45 (03) :219-225

[5] SEQUENCE-SELECTIVE METAL-ION BINDING TO DNA OLIGONUCLEOTIDES [J].

FROYSTEIN, NA ;

DAVIS, JT ;

REID, BR ;

SLETTEN, E .

ACTA CHEMICA SCANDINAVICA, 1993, 47 (07) :649-657

[6] H-1-NMR STRUCTURAL EVIDENCE FOR THE SEQUENCE-SPECIFIC DESIGN OF AN INTERCALATOR - DELTA-ALPHA-[RH[(R,R)-ME(2)TRIEN]PHI](3+) BOUND TO D(GAGTGCACTC)(2) [J].

HUDSON, BP ;

DUPUREUR, CM ;

BARTON, JK .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (36) :9379-9380

[7]

JIA X, 1991, INORG CHEM, V30, P228

[8] Diastereomeric DNA-binding geometries of intercalated ruthenium(II) trischelates probed by linear dichroism: [Ru(phen)(2)DPPZ](2+) and [Ru(phen)(2)BDPPZ](2+) [J].

Lincoln, P ;

Broo, A ;

Norden, B .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1996, 118 (11) :2644-2653

[9] BINDING OF INERT METAL-COMPLEXES TO DEOXYRIBONUCLEIC-ACID DETECTED BY LINEAR DICHROISM [J].

NORDEN, B ;

TJERNELD, F .

FEBS LETTERS, 1976, 67 (03) :368-370

[10]

PATEL DJ, 1986, J BIOL CHEM, V261, P1223

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