NMR study of the sequence-specific binding of the Delta-tris(ethylenediamine)cobalt(III) cation with d(TCGGGATCCCGA)(2)

被引：18

作者：

Fry, JV ^{[1
]}

Collins, JG ^{[1
]}

机构：

[1] UNIV COLL NEW S WALES, SCH CHEM, AUSTRALIAN DEF FORCE ACAD, CANBERRA, ACT 2600, AUSTRALIA

来源：

INORGANIC CHEMISTRY | 1997年 / 36卷 / 13期

关键词：

D O I：

10.1021/ic960937u

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

H-1 NMR spectroscopy was used to study the binding of Delta-Co(en)(3)(3+) to the dodecanucleotide d(TCGGG-GATCCCGA)(2). Intermolecular NOE cross peaks between the metal complex methylene protons and the dodecanucleotide unambiguously establish that Delta-Co(en)(3)(3+) selectively binds at GG sequences in the major groove. The NMR experiments indicated that the dodecanucleotide maintains a B-type DNA conformation upon metal complex binding.

引用

页码：2919 / +

页数：1

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