Emerging influenza

被引:63
作者
de Wit, Emmie
Fouchier, Ron A. M. [1 ]
机构
[1] Erasmus MC, Dept Virol, NL-3000 CA Rotterdam, Netherlands
关键词
influenza A virus; HPA1; pathogenesis;
D O I
10.1016/j.jcv.2007.10.017
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
In 1918 the Spanish influenza pandemic, caused by an avian HIN1 virus, resulted in over 50 million deaths worldwide. Several outbreaks of H7 influenza A viruses have resulted in human cases, including one fatal case. Since 1997, the outbreaks of highly pathogenic avian influenza (HPAI) of the H5N1 subtype have affected a wide variety of mammals in addition to poultry and wild birds. Here, we give an overview of the current knowledge of the determinants of pathogenicity of these three subtypes of avian influenza A virus in mammals. Common mechanisms for acquisition of virulence and replication of these avian influenza viruses in mammals are becoming apparent. Therefore, monitoring these and additional genetic changes upon zoonotic infections is important. Identification of genetic changes responsible for transmission between mammals will be an important task for the near future. (C) 2007 Elsevier B.V. All rights reserved.
引用
收藏
页码:1 / 6
页数:6
相关论文
共 49 条
  • [1] Sequence of the 1918 pandemic influenza virus nonstructural gene (NS) segment and characterization of recombinant viruses hearing the 1918 NS genes
    Basler, CF
    Reid, AH
    Dybing, JK
    Janczewski, TA
    Fanning, TG
    Zheng, HY
    Salvatore, M
    Perdue, ML
    Swayne, DE
    García-Sastre, A
    Palese, P
    Taubenberger, JK
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (05) : 2746 - 2751
  • [2] Current concepts - Avian influenza A (H5N1) infection in humans
    Beigel, H
    Farrar, H
    Han, AM
    Hayden, FG
    Hyer, R
    de Jong, MD
    Lochindarat, S
    Tien, NTK
    Hien, NT
    Hien, TT
    Nicoll, A
    Touch, S
    Yuen, KY
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (13) : 1374 - 1385
  • [3] Thai dogs carry bird-flu virus, but will they spread it?
    Butler, D
    [J]. NATURE, 2006, 439 (7078) : 773 - 773
  • [4] Genomic signatures of human versus avian influenza a viruses
    Chen, Guang-Wu
    Chang, Shih-Cheng
    Mok, Chee-Keng
    Lo, Yu-Luan
    Kung, Yu-Nong
    Huang, Ji-Hung
    Shih, Yun-Han
    Wang, Ji-Yi
    Chiang, Chiayn
    Chen, Chi-Jene
    Shih, Shin-Ru
    [J]. EMERGING INFECTIOUS DISEASES, 2006, 12 (09) : 1353 - 1360
  • [5] Induction of proinflammatory cytokines in human macrophages by influenza A (H5N1) viruses: a mechanism for the unusual severity of human disease?
    Cheung, CY
    Poon, LLM
    Lau, AS
    Luk, W
    Lau, YL
    Shortridge, KF
    Gordon, S
    Guan, Y
    Peiris, JSM
    [J]. LANCET, 2002, 360 (9348) : 1831 - 1837
  • [6] New clues to the emergence of flu pandemics
    Claas, ECJ
    Osterhaus, ADME
    [J]. NATURE MEDICINE, 1998, 4 (10) : 1122 - 1123
  • [7] Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
    de Jong, Menno D.
    Simmons, Cameron P.
    Thanh, Tran Tan
    Hien, Vo Minh
    Smith, Gavin J. D.
    Chau, Tran Nguyen Bich
    Hoang, Dang Minh
    Chau, Nguyen Van Vinh
    Khanh, Truong Huu
    Dong, Vo Cong
    Qui, Phan Tu
    Van Cam, Bach
    Ha, Do Quang
    Guan, Yi
    Peiris, J. S. Malik
    Chinh, Nguyen Tran
    Hien, Tran Tinh
    Farrar, Jeremy
    [J]. NATURE MEDICINE, 2006, 12 (10) : 1203 - 1207
  • [8] A pandemic warning?
    deJong, JC
    Claas, ECJ
    Osterhaus, ADME
    Webster, RG
    Lim, WL
    [J]. NATURE, 1997, 389 (6651) : 554 - 554
  • [9] Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses
    Dybing, JK
    Schultz-Cherry, S
    Swayne, DE
    Suarez, DL
    Perdue, ML
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (03) : 1443 - 1450
  • [10] Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome.
    Fouchier, RAM
    Schneeberger, PM
    Rozendaal, FW
    Broekman, JM
    Kemink, SAG
    Munstert, V
    Kuiken, T
    Rimmelzwaan, GF
    Schutten, M
    van Doornum, GJJ
    Koch, G
    Bosman, A
    Koopmans, M
    Osterhaus, ADME
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) : 1356 - 1361