2,6-Dichloro-9-thiabicyclo[3.3.1]nonane: A privileged, bivalent scaffold for the display of nucleophilic components

被引：39

作者：

Converso, A

Burow, K

Marzinzik, A

Sharpless, KB

Finn, MG

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Ins Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 12期

关键词：

D O I：

10.1021/jo015632y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compound, the condensation product of sulfur dichloride and 1,5-cyclooctadiene, is a reliable acceptor of a wide variety of heteroatom nucleophiles, sometimes in reversible fashion. Optical resolution of the core structure has been achieved and preserved in succeeding transformations. The high reactivity and reliable stereochemical control afforded by this system illustrates the power of neighboring-group participation by the sulfur center.

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页码：4386 / 4392

页数：7

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