Butanol production from renewable biomass: Rediscovery of metabolic pathways and metabolic engineering

被引:109
作者
Jang, Yu-Sin [1 ]
Lee, Joungmin [1 ]
Malaviya, Alok [1 ]
Seung, Do Young [4 ]
Cho, Jung Hee [4 ]
Lee, Sang Yup [1 ,2 ,3 ]
机构
[1] Korea Adv Inst Sci & Technol, Dept Chem & Biomol Engn,Program BK21, Metab & Biomol Engn Natl Res Lab,Inst BioCentury, BioProc Engn Res Ctr,Ctr Syst & Synthet Biotechno, Taejon 305701, South Korea
[2] Korea Adv Inst Sci & Technol, Dept Bio & Brain Engn, Taejon 305701, South Korea
[3] Korea Adv Inst Sci & Technol, Bioinformat Res Ctr, Taejon 305701, South Korea
[4] GS Caltex Corp, Value Creat Ctr, Taejon, South Korea
关键词
Biomass; Butanol; Clostridium; Metabolic engineering; Metabolic pathway; CLOSTRIDIUM-ACETOBUTYLICUM M5; BEIJERINCKII NCIMB 8052; CONTINUOUS CULTURES; CARBON-MONOXIDE; TRANSCRIPTIONAL PROGRAM; FERMENTATIVE PRODUCTION; ENERGY-CONSERVATION; AGRICULTURAL WASTE; SOLVENT TOLERANCE; ESCHERICHIA-COLI;
D O I
10.1002/biot.201100059
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Biofuel from renewable biomass is one of the answers to help solve the problems associated with limited fossil resources and climate change. Butanol has superior liquid-fuel characteristics, with similar properties to gasoline, and thus, has the potential to be used as a substitute for gasoline. Clostridia are recognized as a good butanol producers and are employed in the industrial-scale production of solvents. Due to the difficulty of performing genetic manipulations on clostridia, however, strain improvement has been rather slow. Furthermore, complex metabolic characteristics of acidogenesis followed by solventogenesis in this strain have hampered the development of engineered clostridia strains with highly efficient and selective butanol-production capabilities. In recent years, the butanol-producing characteristics in clostridia have been further characterized and alternative pathways discovered. More recently, systems-level metabolic engineering approaches were taken to develop superior strains. Herein, we review recent discoveries of metabolic pathways for butanol production and the metabolic engineering strategies being developed.
引用
收藏
页码:186 / 198
页数:13
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