Inhibition of EphA4 signaling after ischemia-reperfusion reduces apoptosis of CA1 pyramidal neurons

被引：26

作者：

Li, Jianguo ^{[1
]}

Liu, Naihong ^{[1
]}

Wang, Ye ^{[1
]}

Wang, Rui ^{[1
]}

Guo, Dawei ^{[2
]}

Zhang, Ce ^{[1
]}

机构：

[1] Shanxi Med Univ, Dept Physiol, Taiyuan 030001, Peoples R China

[2] Shanxi Med Univ, Dept Forens Biol, Taiyuan 030001, Peoples R China

来源：

NEUROSCIENCE LETTERS | 2012年 / 518卷 / 02期

关键词：

EphA4; EphA4-Fc; Hippocampal neuron; Ischemia-reperfusion; Apoptosis; RECEPTOR; BRAIN; MECHANISMS; PROLIFERATION; GLIA;

D O I：

10.1016/j.neulet.2012.04.060

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Hippocampal CA1 pyramidal neurons are sensitive to ischemic damage. However, the cellular and molecular mechanisms underlying neuronal cell death caused by ischemia-reperfusion (I/R) are not completely clear. Here, we report that the ephrinA/EphA cell-cell interaction signaling pathway plays an important role in the apoptosis of hippocampal CA1 pyramidal neurons induced by I/R. We found that the expression of ephrinA3 and EphA4 is increased in the CA1 region following transient forebrain ischemia. Blocking ephrinA3/EphA4 interaction by EphA4-Fc, an inhibitor of EphA4, attenuated apoptotic neuronal cell death, likely through the inhibition of caspase-3 activation. These results reveal a novel function of ephrin/Eph signaling in the regulation of apoptosis in CA1 pyramidal neurons after I/R. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：92 / 95

页数：4

相关论文

共 26 条

[1]

Signaling between glia and neurons: focus on synaptic plasticity [J].

Allen, NJ ;

Barres, BA .

CURRENT OPINION IN NEUROBIOLOGY, 2005, 15 (05) :542-548

[2]

Ephrin signalling controls brain size by regulating apoptosis of neural progenitors [J].

Depaepe, V ;

Suarez-Gonzalez, N ;

Dufour, A ;

Passante, L ;

Gorski, JA ;

Jones, KR ;

Ledent, C ;

Vanderhaeghen, P .

NATURE, 2005, 435 (7046) :1244-1250

[3]

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis [J].

Dohn, M ;

Jiang, JY ;

Chen, XB .

ONCOGENE, 2001, 20 (45) :6503-6515

[4]

Inhibition of EphA7 up-regulation after spinal cord injury reduces apoptosis and promotes locomotor recovery [J].

Figueroa, Johnny D. ;

Benton, Richard L. ;

Velazquez, Ixane ;

Torrado, Aranza I. ;

Ortiz, Cristina. M. ;

Hernandez, Carmen M. ;

Diaz, Juan J. ;

Magnuson, David S. ;

Whittemore, Scott R. ;

Miranda, Jorge D. .

JOURNAL OF NEUROSCIENCE RESEARCH, 2006, 84 (07) :1438-1451

[5]

Neuron-glia communication via EphA4/ephrin-A3 modulates LTP through glial glutamate transport [J].

Filosa, Alessandro ;

Paixao, Sonia ;

Honsek, Silke D. ;

Carmona, Maria A. ;

Becker, Lore ;

Feddersen, Berend ;

Gaitanos, Louise ;

Rudhard, York ;

Schoepfer, Ralf ;

Klopstock, Thomas ;

Kullander, Klas ;

Rose, Christine R. ;

Pasquale, Elena B. ;

Klein, Ruediger .

NATURE NEUROSCIENCE, 2009, 12 (10) :1285-U106

[6]

A Presynaptic Homeostatic Signaling System Composed of the Eph Receptor, Ephexin, Cdc42, and CaV2.1 Calcium Channels [J].

Frank, C. Andrew ;

Pielage, Jan ;

Davis, Graeme W. .

NEURON, 2009, 61 (04) :556-569

[7]

Roles of Eph receptors and ephrins in the normal and damaged adult CNS [J].

Goldshmit, Yona ;

McLenachan, Samuel ;

Turnley, Ann .

BRAIN RESEARCH REVIEWS, 2006, 52 (02) :327-345

[8]

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis [J].

Holmberg, J ;

Armulik, A ;

Senti, KA ;

Edoff, K ;

Spalding, K ;

Momma, S ;

Cassidy, R ;

Flanagan, JG ;

Frisén, J .

GENES & DEVELOPMENT, 2005, 19 (04) :462-471

[9]

Horvitz HR, 1999, CANCER RES, V59, p1701S

[10]

Stroke research at a crossroad: asking the brain for directions [J].

Iadecola, Costantino ;

Anrather, Josef .

NATURE NEUROSCIENCE, 2011, 14 (11) :1363-1368