Neuronal activity in the substantia nigra in the anaesthetized rat has fractal characteristics.: Evidence for firing-code patterns in the basal ganglia

被引：25

作者：

Rodríguez, M

Pereda, E

González, J

Abdala, P

Obeso, JA

机构：

[1] Univ La Laguna, Dept Physiol, Fac Med, Tenerife, Canary Islands, Spain

[2] Univ La Laguna, Dept Basic Phys, Fac Phys, Tenerife, Canary Islands, Spain

[3] Univ Navarra, Ctr Neurosci, Dept Neurol & Neurosurg, Clin Univ, E-31080 Pamplona, Spain

[4] Univ Navarra, Sch Med, E-31080 Pamplona, Spain

来源：

EXPERIMENTAL BRAIN RESEARCH | 2003年 / 151卷 / 02期

关键词：

fractal; substantia nigra; basal ganglia; GABA cell; dopamine cell; ORGANIZATION; RESPONSES; MIDBRAIN; SYSTEM; SIGNAL; MOTOR;

D O I：

10.1007/s00221-003-1442-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Current models of the basal ganglia assume a firing-rate code for information processing. We have applied five complementary computing methods to assess firing patterns in 188 cells of the substantia nigra in the anaesthetized rat. Fractal firing activity was found in 100% of nigral cells projecting to the superior colliculus, in 51% of cells projecting to the thalamus and in 33% of cells projecting to the pedunculopontine nucleus, but was practically absent in dopaminergic nigrostriatal neurons (3%). The finding of fractal firing patterns may lead to a better understanding of the normal operational mode and pathological manifestations of the basal ganglia.

引用

页码：167 / 172

页数：6