Synergistic interactions between mammalian antimicrobial defense peptides

被引：205

作者：

Yan, H ^{[1
]}

Hancock, REW ^{[1
]}

机构：

[1] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z3, Canada

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 05期

关键词：

D O I：

10.1128/AAC.45.5.1558-1560.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A single animal can express several cationic antimicrobial peptides with different sequences and structures. We demonstrate that mammalian peptides from different structural classes frequently show synergy with each other and selectively show synergy with human lysozyme.

引用

页码：1558 / 1560

页数：3

共 15 条

[1]

Amsterdam D., 1996, Antibiotics in laboratory medicine, V6th ed.

[2] Neutrophil antibacterial peptides, multifunctional effector molecules in the mammalian immune system [J].

Gudmundsson, GH ;

Agerberth, B .

JOURNAL OF IMMUNOLOGICAL METHODS, 1999, 232 (1-2) :45-54

[3] The role of antimicrobial peptides in animal defenses [J].

Hancock, REW ;

Scott, MG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (16) :8856-8861

[4] Cationic peptides: a new source of antibiotics [J].

Hancock, REW ;

Lehrer, R .

TRENDS IN BIOTECHNOLOGY, 1998, 16 (02) :82-88

[5] The role of cationic antimicrobial peptides in innate host defences [J].

Hancock, REW ;

Diamond, G .

TRENDS IN MICROBIOLOGY, 2000, 8 (09) :402-410

[6] ULTRASENSITIVE ASSAYS FOR ENDOGENOUS ANTIMICROBIAL POLYPEPTIDES [J].

LEHRER, RI ;

ROSENMAN, M ;

HARWIG, SSSL ;

JACKSON, R ;

EISENHAUER, P .

JOURNAL OF IMMUNOLOGICAL METHODS, 1991, 137 (02) :167-173

[7] INDIVIDUAL AND SYNERGISTIC EFFECTS OF RABBIT GRANULOCYTE PROTEINS ON ESCHERICHIA-COLI [J].

LEVY, O ;

OOI, CE ;

WEISS, J ;

LEHRER, RI ;

ELSBACH, P .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (02) :672-682

[8] Mechanism of synergism between antimicrobial peptides magainin 2 and PGLa [J].

Matsuzaki, K ;

Mitani, Y ;

Akada, K ;

Murase, O ;

Yoneyama, S ;

Zasloff, M ;

Miyajima, K .

BIOCHEMISTRY, 1998, 37 (43) :15144-15153

[9]

Meister M, 2000, CURR TOP MICROBIOL, V248, P17

[10]

MOR A, 1994, J BIOL CHEM, V269, P31635

← 1 2 →