Bruton and Tec: New links in osteoimmunology

被引:18
作者
Boyce, Brendan F. [1 ]
Xing, Lianping [1 ]
机构
[1] Univ Rochester, Med Ctr, Rochester, NY 14534 USA
关键词
D O I
10.1016/j.cmet.2008.03.013
中图分类号
Q2 [细胞生物学];
学科分类号
071009 [细胞生物学]; 090102 [作物遗传育种];
摘要
Enhanced and deficient immune responses are associated with abnormal bone homeostasis. A new study by Shinohara et al. (2008) shows that protein phosphorylation by the tyrosine kinases Bruton and Tec links immunity and bone as well as two signaling pathways in precursors of osteoclasts, the cells that degrade bone.
引用
收藏
页码:283 / 285
页数:3
相关论文
共 12 条
[1]
Osteoclast precursors: cytokine-stimulated immunomodulators of inflammatory bone disease [J].
Boyce, Brendan F. ;
Schwarz, Edward M. ;
Xing, Lianping .
CURRENT OPINION IN RHEUMATOLOGY, 2006, 18 (04) :427-432
[2]
Regulation of vascular calcification by osteoclast regulatory factors RANKL and osteoprotegerin [J].
Collin-Osdoby, P .
CIRCULATION RESEARCH, 2004, 95 (11) :1046-1057
[3]
Severe B cell deficiency in mice lacking the Tec kinase family members Tec and Btk [J].
Ellmeier, W ;
Jung, S ;
Sunshine, MJ ;
Hatam, F ;
Xu, Y ;
Baltimore, D ;
Mano, H ;
Littman, DR .
JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (11) :1611-1623
[4]
Reaching a genetic and molecular understanding of skeletal development [J].
Karsenty, G ;
Wagner, EF .
DEVELOPMENTAL CELL, 2002, 2 (04) :389-406
[5]
The immune response is involved in atherosclerotic plaque calcification: Could the RANKL/RANK/OPG system be a marker of plaque instability? [J].
Montecucco, Fabrizio ;
Steffens, Sabine ;
Mach, Francois .
CLINICAL & DEVELOPMENTAL IMMUNOLOGY, 2007, :75805
[6]
Up-regulation of TNF-producing T cells in the bone marrow:: A key mechanism by which estrogen deficiency induces bone loss in vivo [J].
Roggia, C ;
Gao, YH ;
Cenci, S ;
Weitzmann, MN ;
Toraldo, G ;
Isaia, G ;
Pacifici, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (24) :13960-13965
[7]
New roles for osteoclasts in bone [J].
Royce, Brendan F. ;
Yao, Zhenqiang ;
Zhang, Qian ;
Guo, Roulin ;
Lu, Yan ;
Schwarz, Edward M. ;
Xing, Lianping .
SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING, 2007, 1116 :245-254
[8]
Bone weighs in on obesity [J].
Semenkovich, Clay F. ;
Teitelbaum, Steven L. .
CELL, 2007, 130 (03) :409-411
[9]
Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals [J].
Shinohara, Masahiro ;
Koga, Takako ;
Okamoto, Kazuo ;
Sakaguchi, Shinya ;
Arai, Kimiko ;
Yasuda, Hisataka ;
Takai, Toshiyuki ;
Kodama, Tatsuhiko ;
Morio, Tomohiro ;
Geha, Raif S. ;
Kitamura, Daisuke ;
Kurosaki, Tomohiro ;
Ellmeier, Wilfried ;
Takayanagi, Hiroshi .
CELL, 2008, 132 (05) :794-806
[10]
Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems [J].
Takayanagi, Hiroshi .
NATURE REVIEWS IMMUNOLOGY, 2007, 7 (04) :292-304