Limited agreement between biomarkers of neuronal injury at different stages of Alzheimer's disease

被引：48

作者：

Alexopoulos, Panagiotis ^{[1
,2
]}

Kriett, Laura ^{[3
]}

Haller, Bernhard ^{[4
]}

Klupp, Elisabeth ^{[3
]}

Gray, Katherine ^{[5
]}

Grimmer, Timo ^{[1
]}

Laskaris, Nikolaos ^{[6
]}

Foerster, Stefan ^{[3
]}

Perneczky, Robert ^{[1
,7
,8
]}

Kurz, Alexander ^{[1
]}

Drzezga, Alexander ^{[9
]}

Fellgiebel, Andreas ^{[10
]}

Yakushev, Igor ^{[3
]}

机构：

[1] Tech Univ Munich, Dept Psychiat & Psychotherapy, D-80290 Munich, Germany

[2] Univ Patras, Dept Psychiat, Rion, Greece

[3] Tech Univ Munich, Dept Nucl Med, D-80290 Munich, Germany

[4] Tech Univ Munich, Inst Med Stat & Epidemiol, D-80290 Munich, Germany

[5] Univ London Imperial Coll Sci Technol & Med, Dept Comp, Biomed Image Anal Grp, London SW7 2AZ, England

[6] Aristotle Univ Thessaloniki, Dept Informat, GR-54006 Thessaloniki, Greece

[7] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Neuroepidemiol & Ageing Res Unit, London, England

[8] West London Mental Hlth Trust, West London Cognit Disorders Treatment & Res Unit, London, England

[9] Univ Cologne, Dept Nucl Med, D-50931 Cologne, Germany

[10] Univ Med Ctr Mainz, Dept Psychiat & Psychotherapy, Mainz, Germany

来源：

ALZHEIMERS & DEMENTIA | 2014年 / 10卷 / 06期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

Dementia; Agreement; Diagnostic criteria; Tau; FDG-PET; Hippocampal atrophy; MILD COGNITIVE IMPAIRMENT; NATIONAL INSTITUTE; ASSOCIATION WORKGROUPS; DIAGNOSTIC GUIDELINES; RECOMMENDATIONS; DEMENTIA; ADNI; CORE;

D O I：

10.1016/j.jalz.2014.03.006

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

New diagnostic criteria for Alzheimer's disease (AD) treat different biomarkers of neuronal injury as equivalent. Here, we quantified the degree of agreement between hippocampal volume on structural magnetic resonance imaging, regional glucose metabolism on positron emission tomography, and levels of phosphorylated tau in cerebrospinal fluid (CSF) in 585 subjects from all phases of the AD Neuroimaging Initiative. The overall chance-corrected agreement was poor (Cohen kappa, 0.24-0.34), in accord with a high rate of conflicting findings (26%-41%). Neither diagnosis nor APOE epsilon 4 status significantly influenced the distribution of agreement between the biomarkers. The degree of agreement tended to be higher in individuals with abnormal versus normal CSF beta-am-yloid (A beta(1-42)) levels. Prospective diagnostic criteria for AD should address the relative importance of markers of neuronal injury and elaborate a way of dealing with conflicting biomarker findings. (C) 2014 The Alzheimer's Association. All rights reserved.

引用

页码：684 / 689

页数：6

共 20 条

[1] Clinical core of the Alzheimer's disease neuroimaging initiative: Progress and plans [J].

Aisen, Paul S. ;

Petersen, Ronald C. ;

Donohue, Michael C. ;

Gamst, Anthony ;

Raman, Rema ;

Thomas, Ronald G. ;

Walter, Sarah ;

Trojanowski, John Q. ;

Shaw, Leslie M. ;

Beckett, Laurel A. ;

Jack, Clifford R., Jr. ;

Jagust, William ;

Toga, Arthur W. ;

Saykin, Andrew J. ;

Morris, John C. ;

Green, Robert C. ;

Weiner, Michael W. .

ALZHEIMERS & DEMENTIA, 2010, 6 (03) :239-246

[2] The diagnosis of mild cognitive impairment due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease [J].

Albert, Marilyn S. ;

DeKosky, Steven T. ;

Dickson, Dennis ;

Dubois, Bruno ;

Feldman, Howard H. ;

Fox, Nick C. ;

Gamst, Anthony ;

Holtzman, David M. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Snyder, Peter J. ;

Carrillo, Maria C. ;

Thies, Bill ;

Phelps, Creighton H. .

ALZHEIMERS & DEMENTIA, 2011, 7 (03) :270-279

[3]

[Anonymous], 2003, Statistical Methods for Rates and Proportions

[4] Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Aβ42 in humans [J].

Fagan, AM ;

Mintun, MA ;

Mach, RH ;

Lee, SY ;

Dence, CS ;

Shah, AR ;

LaRossa, GN ;

Spinner, ML ;

Klunk, WE ;

Mathis, CA ;

DeKosky, ST ;

Morris, JC ;

Holtzman, DM .

ANNALS OF NEUROLOGY, 2006, 59 (03) :512-519

[5] Imaging markers for Alzheimer disease Which vs how [J].

Frisoni, Giovanni B. ;

Bocchetta, Martina ;

Chetelat, Gael ;

Rabinovici, Gil D. ;

de Leon, Mony J. ;

Kaye, Jeffrey ;

Reiman, Eric M. ;

Scheltens, Philip ;

Barkhof, Frederik ;

Black, Sandra E. ;

Brooks, David J. ;

Carrillo, Maria C. ;

Fox, Nick C. ;

Herholz, Karl ;

Nordberg, Agneta ;

Jack, Clifford R., Jr. ;

Jagust, William J. ;

Johnson, Keith A. ;

Rowe, Christopher C. ;

Sperling, Reisa A. ;

Thies, William ;

Wahlund, Lars-Olof ;

Weiner, Michael W. ;

Pasqualetti, Patrizio ;

DeCarli, Charles .

NEUROLOGY, 2013, 81 (05) :487-500

[6] The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods [J].

Jack, Clifford R., Jr. ;

Bernstein, Matt A. ;

Fox, Nick C. ;

Thompson, Paul ;

Alexander, Gene ;

Harvey, Danielle ;

Borowski, Bret ;

Britson, Paula J. ;

Whitwell, Jennifer L. ;

Ward, Chadwick ;

Dale, Anders M. ;

Felmlee, Joel P. ;

Gunter, Jeffrey L. ;

Hill, Derek L. G. ;

Killiany, Ron ;

Schuff, Norbert ;

Fox-Bosetti, Sabrina ;

Lin, Chen ;

Studholme, Colin ;

DeCarli, Charles S. ;

Krueger, Gunnar ;

Ward, Heidi A. ;

Metzger, Gregory J. ;

Scott, Katherine T. ;

Mallozzi, Richard ;

Blezek, Daniel ;

Levy, Joshua ;

Debbins, Josef P. ;

Fleisher, Adam S. ;

Albert, Marilyn ;

Green, Robert ;

Bartzokis, George ;

Glover, Gary ;

Mugler, John ;

Weiner, Michael W. .

JOURNAL OF MAGNETIC RESONANCE IMAGING, 2008, 27 (04) :685-691

[7] Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers [J].

Jack, Clifford R., Jr. ;

Knopman, David S. ;

Jagust, William J. ;

Petersen, Ronald C. ;

Weiner, Michael W. ;

Aisen, Paul S. ;

Shaw, Leslie M. ;

Vemuri, Prashanthi ;

Wiste, Heather J. ;

Weigand, Stephen D. ;

Lesnick, Timothy G. ;

Pankratz, Vernon S. ;

Donohue, Michael C. ;

Trojanowski, John Q. .

LANCET NEUROLOGY, 2013, 12 (02) :207-216

[8] An operational approach to National Institute on Aging-Alzheimer's Association criteria for preclinical Alzheimer disease [J].

Jack, Clifford R., Jr. ;

Knopman, David S. ;

Weigand, Stephen D. ;

Wiste, Heather J. ;

Vemuri, Prashanthi ;

Lowe, Val ;

Kantarci, Kejal ;

Gunter, Jeffrey L. ;

Senjem, Matthew L. ;

Ivnik, Robert J. ;

Roberts, Rosebud O. ;

Rocca, Walter A. ;

Boeve, Bradley F. ;

Petersen, Ronald C. .

ANNALS OF NEUROLOGY, 2012, 71 (06) :765-775

[9] Relationships between biomarkers in aging and dementia [J].

Jagust, W. J. ;

Landau, S. M. ;

Shaw, L. M. ;

Trojanowski, J. Q. ;

Koeppe, R. A. ;

Reiman, E. M. ;

Foster, N. L. ;

Petersen, R. C. ;

Weiner, M. W. ;

Price, J. C. ;

Mathis, C. A. .

NEUROLOGY, 2009, 73 (15) :1193-1199

[10] The Alzheimer's Disease Neuroimaging Initiative positron emission tomography core [J].

Jagust, William J. ;

Bandy, Dan ;

Chen, Kewei ;

Foster, Norman L. ;

Landau, Susan M. ;

Mathis, Chester A. ;

Price, Julie C. ;

Reiman, Eric M. ;

Skovronsky, Daniel ;

Koeppe, Robert A. .

ALZHEIMERS & DEMENTIA, 2010, 6 (03) :221-229

← 1 2 →