A new era for Type 2 diabetes genetics

被引:31
作者
Zeggini, E. [1 ]
机构
[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
关键词
genome-wide association; type; 2; diabetes;
D O I
10.1111/j.1464-5491.2007.02274.x
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
[No abstract available]
引用
收藏
页码:1181 / 1186
页数:6
相关论文
共 33 条
[1]
A haplotype map of the human genome [J].
Altshuler, D ;
Brooks, LD ;
Chakravarti, A ;
Collins, FS ;
Daly, MJ ;
Donnelly, P ;
Gibbs, RA ;
Belmont, JW ;
Boudreau, A ;
Leal, SM ;
Hardenbol, P ;
Pasternak, S ;
Wheeler, DA ;
Willis, TD ;
Yu, FL ;
Yang, HM ;
Zeng, CQ ;
Gao, Y ;
Hu, HR ;
Hu, WT ;
Li, CH ;
Lin, W ;
Liu, SQ ;
Pan, H ;
Tang, XL ;
Wang, J ;
Wang, W ;
Yu, J ;
Zhang, B ;
Zhang, QR ;
Zhao, HB ;
Zhao, H ;
Zhou, J ;
Gabriel, SB ;
Barry, R ;
Blumenstiel, B ;
Camargo, A ;
Defelice, M ;
Faggart, M ;
Goyette, M ;
Gupta, S ;
Moore, J ;
Nguyen, H ;
Onofrio, RC ;
Parkin, M ;
Roy, J ;
Stahl, E ;
Winchester, E ;
Ziaugra, L ;
Shen, Y .
NATURE, 2005, 437 (7063) :1299-1320
[2]
The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[3]
Evaluating coverage of genome-wide association studies [J].
Barrett, Jeffrey C. ;
Cardon, Lon R. .
NATURE GENETICS, 2006, 38 (06) :659-662
[4]
Functional variation and evolution of non-coding DNA [J].
Bird, Christine P. ;
Stranger, Barbara E. ;
Dermitzakis, Emmanouil T. .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2006, 16 (06) :559-564
[5]
Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas [J].
Bort, R ;
Martinez-Barbera, JP ;
Beddington, RSP ;
Zaret, KS .
DEVELOPMENT, 2004, 131 (04) :797-806
[6]
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[7]
Variation in FTO contributes to childhood obesity and severe adult obesity [J].
Dina, Christian ;
Meyre, David ;
Gallina, Sophie ;
Durand, Emmanuelle ;
Koerner, Antje ;
Jacobson, Peter ;
Carlsson, Lena M. S. ;
Kiess, Wieland ;
Vatin, Vincent ;
Lecoeur, Cecile ;
Delplanque, Jerome ;
Vaillant, Emmanuel ;
Pattou, Francois ;
Ruiz, Juan ;
Weill, Jacques ;
Levy-Marchal, Claire ;
Horber, Fritz ;
Potoczna, Natascha ;
Hercberg, Serge ;
Le Stunff, Catherine ;
Bougneres, Pierre ;
Kovacs, Peter ;
Marre, Michel ;
Balkau, Beverley ;
Cauchi, Stephane ;
Chevre, Jean-Claude ;
Froguel, Philippe .
NATURE GENETICS, 2007, 39 (06) :724-726
[8]
High-density haplotype structure and association testing of the insulin-degrading enzyme (IDE) gene with type 2 diabetes in 4,206 people [J].
Florez, JC ;
Wiltshire, S ;
Agapakis, CM ;
Burtt, NP ;
de Bakker, PIW ;
Almgren, P ;
Boström, KB ;
Tuomi, T ;
Gaudet, D ;
Daly, MJ ;
Hirschhorn, JN ;
McCarthy, MI ;
Altshuler, D ;
Groop, L .
DIABETES, 2006, 55 (01) :128-135
[9]
Heart induction by Wnt antagonists depends on the homeodomain transcription factor Hex [J].
Foley, AC ;
Mercola, M .
GENES & DEVELOPMENT, 2005, 19 (03) :387-396
[10]
A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity [J].
Frayling, Timothy M. ;
Timpson, Nicholas J. ;
Weedon, Michael N. ;
Zeggini, Eleftheria ;
Freathy, Rachel M. ;
Lindgren, Cecilia M. ;
Perry, John R. B. ;
Elliott, Katherine S. ;
Lango, Hana ;
Rayner, Nigel W. ;
Shields, Beverley ;
Harries, Lorna W. ;
Barrett, Jeffrey C. ;
Ellard, Sian ;
Groves, Christopher J. ;
Knight, Bridget ;
Patch, Ann-Marie ;
Ness, Andrew R. ;
Ebrahim, Shah ;
Lawlor, Debbie A. ;
Ring, Susan M. ;
Ben-Shlomo, Yoav ;
Jarvelin, Marjo-Riitta ;
Sovio, Ulla ;
Bennett, Amanda J. ;
Melzer, David ;
Ferrucci, Luigi ;
Loos, Ruth J. F. ;
Barroso, Ines ;
Wareham, Nicholas J. ;
Karpe, Fredrik ;
Owen, Katharine R. ;
Cardon, Lon R. ;
Walker, Mark ;
Hitman, Graham A. ;
Palmer, Colin N. A. ;
Doney, Alex S. F. ;
Morris, Andrew D. ;
Smith, George Davey ;
Hattersley, Andrew T. ;
McCarthy, Mark I. .
SCIENCE, 2007, 316 (5826) :889-894