Drug-protein interactions: Two-site binding of heterocyclic ligands to a monomeric hemoglobin

被引：143

作者：

Stephanos, JJ ^{[1
]}

机构：

[1] DREXEL UNIV, DEPT CHEM, PHILADELPHIA, PA 19104 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 1996年 / 62卷 / 03期

关键词：

D O I：

10.1016/0162-0134(95)00144-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reactivity response of the heme proteins to the heterotropic effecters, purine, caffeine, theophylline, and (C2H5N+, have been examined. The heterotropic effecters influence the heme ligation affinities. The heme axial ligation of pyridine and pyrazole;have not influenced the hemoglobin's affinity for caffeine and theophylline. The imidazole ligation indicates a mutual interaction between the heme active site and the noncoordinate binding site.

引用

页码：155 / 169

页数：15