Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

被引：1221

作者：

Chen, Q. ^{[1
,2
,4
]}

Shou, P. ^{[2
]}

Zheng, C. ^{[2
]}

Jiang, M. ^{[2
]}

Cao, G. ^{[2
]}

Yang, Q. ^{[2
]}

Cao, J. ^{[2
]}

Xie, N. ^{[2
]}

Velletri, T. ^{[2
]}

Zhang, X. ^{[2
]}

Xu, C. ^{[2
]}

Zhang, L. ^{[1
,3
]}

Yang, H. ^{[1
]}

Hou, J. ^{[1
]}

Wang, Y. ^{[2
]}

Shi, Y. ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Inst Translat Med, Affiliated Hosp 1, Suzhou 215006, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Hlth Sci, Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China

[3] Rutgers Robert Wood Johnson Med Sch, Child Hlth Inst New Jersey, New Brunswick, NJ 08901 USA

[4] NIEHS, NIH, POB 12233, Res Triangle Pk, NC 27709 USA

来源：

CELL DEATH AND DIFFERENTIATION | 2016年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

FIBROBLAST-GROWTH-FACTOR; HUMAN ADIPOSE-TISSUE; MARROW STROMAL CELLS; OSTEOGENIC DIFFERENTIATION; BONE-MARROW; ADIPOGENIC DIFFERENTIATION; TGF-BETA; INTERNATIONAL-SOCIETY; TRANSCRIPTION FACTOR; SONIC HEDGEHOG;

D O I：

10.1038/cdd.2015.168

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Mesenchymal stem cells (MSCs), a non-hematopoietic stem cell population first discovered in bone marrow, are multipotent cells capable of differentiating into mature cells of several mesenchymal tissues, such as fat and bone. As common progenitor cells of adipocytes and osteoblasts, MSCs are delicately balanced for their differentiation commitment. Numerous in vitro investigations have demonstrated that fat-induction factors inhibit osteogenesis, and, conversely, bone-induction factors hinder adipogenesis. In fact, a variety of external cues contribute to the delicate balance of adipo-osteogenic differentiation of MSCs, including chemical, physical, and biological factors. These factors trigger different signaling pathways and activate various transcription factors that guide MSCs to commit to either lineage. The dysregulation of the adipo-osteogenic balance has been linked to several pathophysiologic processes, such as aging, obesity, osteopenia, osteopetrosis, and osteoporosis. Thus, the regulation of MSC differentiation has increasingly attracted great attention in recent years. Here, we review external factors and their signaling processes dictating the reciprocal regulation between adipocytes and osteoblasts during MSC differentiation and the ultimate control of the adipo-osteogenic balance.

引用

页码：1128 / 1139

页数：12

共 155 条

[1]

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton [J].