N-Acetylcysteine -: a safe antidote for cysteine/glutathione deficiency

被引：594

作者：

Atkuri, Kondala R. ^{[1
]}

Mantovani, John J. ^{[1
]}

Herzenberg, Leonard A. ^{[1
]}

Herzenberg, Leonore A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Genet, Beckman Ctr B007, Stanford, CA 94305 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2007年 / 7卷 / 04期

关键词：

D O I：

10.1016/j.coph.2007.04.005

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

Glutathione (GSH) deficiency is associated with numerous pathological conditions. Administration of N-acetylcysteine (NAC), a cysteine prodrug, replenishes intracellular GSH levels. NAC, best known for its ability to counter acetaminophen toxicity, is a safe, well-tolerated antidote for cysteine/GSH deficiency. NAC has been used successfully to treat GSH deficiency in a wide range of infections, genetic defects and metabolic disorders, including HIV infection and COPD. Over two-thirds of 46 placebo-controlled clinical trials with orally administered NAC have indicated beneficial effects of NAC measured either as trial endpoints or as general measures of improvement in quality of life and well-being of the patients.

引用

页码：355 / 359

页数：5

共 45 条

[1]

Controlled trial of N-acetyleysteine for patients with probable Alzheimer's disease [J].

Adair, JC ;

Knoefel, JE ;

Morgan, N .

NEUROLOGY, 2001, 57 (08) :1515-1517

[2]

N-acetylcysteine - passe-partout or much ado about nothing? [J].

Aitio, ML .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2006, 61 (01) :5-15

[3]

Effect of N-acetylcysteine(NAC) treatment on HIV-1 infection: A double blind placebo controlled trial [J].

Akerlund, B ;

Jarstrand, C ;

Lindeke, B ;

Sonnerborg, A ;

Akerblad, AC ;

Rasool, O .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1996, 50 (06) :457-461

[4]

Andrus JP, 2001, BRIT MED J, V323, P634

[5]

THE ANTIOXIDANT ACTION OF N-ACETYLCYSTEINE - ITS REACTION WITH HYDROGEN-PEROXIDE, HYDROXYL RADICAL, SUPEROXIDE, AND HYPOCHLOROUS ACID [J].

ARUOMA, OI ;

HALLIWELL, B ;

HOEY, BM ;

BUTLER, J .

FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (06) :593-597

[6]

Cysteine supplementation improves the erythrocyte glutathione synthesis rate in children with severe edematous malnutrition [J].

Badaloo, A ;

Reid, M ;

Forrester, T ;

Heird, WC ;

Jahoor, F .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2002, 76 (03) :646-652

[7]

BONANOMI L, 1980, EUR J RESPIR DIS, V61, P45

[8]

Improvement of immune functions in HIV infection by sulfur supplementation:: Two randomized trials [J].

Breitkreutz, R ;

Pittack, N ;

Nebe, CT ;

Schuster, D ;

Brust, J ;

Beichert, M ;

Hack, V ;

Daniel, V ;

Edler, L ;

Dröge, W .

JOURNAL OF MOLECULAR MEDICINE-JMM, 2000, 78 (01) :55-62

[9]

CYSTEINE AND GLUTATHIONE CONCENTRATIONS IN PLASMA AND BRONCHOALVEOLAR LAVAGE FLUID AFTER TREATMENT WITH N-ACETYLCYSTEINE [J].

BRIDGEMAN, MME ;

MARSDEN, M ;

MACNEE, W ;

FLENLEY, DC ;

RYLE, AP .

THORAX, 1991, 46 (01) :39-42

[10]

Cotgreave I A, 1997, Adv Pharmacol, V38, P205

← 1 2 3 4 5 →