Association of tau gene polymorphism with Parkinson's disease

被引：9

作者：

Zappia, M

Annesi, G

Nicoletti, G

Serra, P

Arabia, G

Pugliese, P

Messina, D

Caracciolo, M

Romeo, N

Annesi, F

Pasqua, AA

Spadafora, P

Civitelli, D

Romeo, N

Epifanio, A

Morgante, L

Quattrone, A

机构：

[1] Univ Catanzaro, Neurol Clin, Catanzaro, Italy

[2] CNR, Ist Sci Neurol, Piano Lago Mangone, CS, Italy

[3] Univ Messina, Dipartimento Neurosci, I-98100 Messina, Italy

来源：

NEUROLOGICAL SCIENCES | 2003年 / 24卷 / 03期

关键词：

D O I：

10.1007/s10072-003-0141-z

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We investigated the segregation of the dinucleotide GT repeat polymorphism in the intron between exons 9 and 10 of the tau gene in 300 patients with Parkinson's disease (PD) and in 197 normal controls. The A3 allele was more frequent in cases than in controls (30% versus 16%, p < 0.001), and individuals carrying at least one A3 allele in their genotype had an increased risk of developing PD (odds ratio 2.78, 95% confidence interval 1.81-4.29). No significant differences were found between patients by considering the age at onset and the presence of family history or dementia. Our findings suggest a possible involvement of the tau gene in the pathogenesis of PD.

引用

页码：223 / 224

页数：2

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