Stereoselective synthesis of L-[1-C-13], L-[2-C-13] and L-[N-15] amino acids

被引：39

作者：

Martin, A ^{[1
]}

Chassaing, G ^{[1
]}

Vanhove, A ^{[1
]}

机构：

[1] UNIV PARIS 06,CHIM ORGAN BIOL LAB,URA CNRS 4934,F-75252 PARIS 05,FRANCE

来源：

ISOTOPES IN ENVIRONMENTAL AND HEALTH STUDIES | 1996年 / 32卷 / 01期

关键词：

amino acids; biochemistry; carbon; 13; nitrogen; 15; nutrition; stable isotopes; stereochemistry; synthesis;

D O I：

10.1080/10256019608036289

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The precursor N-(diphenylmethylene) glycinyl camphor sultam has been specifically labelled by nitrogen-15 or carbon-13 starting from either NH4Cl, (K2CO3)-C-13 or (CH3NH2)-C-13 or labelled glycine. Akylation of these different labelled precursors by corresponding electrophiles yielded the following labelled amino acids: Leu, Phe, Ala, Val, Ser, Asn, Gin, Asp, Trp and Cys.

引用

页码：15 / 19

页数：5

共 10 条

[1]

Eck J. C., 1943, ORG SYNTH COLLECT, V2, P76

[2] A FACILE PREPARATION OF DIALKYL CARBONATES FROM POTASSIUM CARBONATE AND ALKYL BROMIDES BY USING ORGANOSTANNYL COMPOUND AS A CATALYST [J].