Strategies for mapping and cloning quantitative trait genes in rodents

被引：386

作者：

Flint, J ^{[1
]}

Valdar, W ^{[1
]}

Shifman, S ^{[1
]}

Mott, R ^{[1
]}

机构：

[1] Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England

来源：

NATURE REVIEWS GENETICS | 2005年 / 6卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nrg1576

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Over the past 15 years, more than 2,000 quantitative trait loci (QTLs) have been identified in crosses between inbred strains of mice and rats, but less than 1% have been characterized at a molecular level. However, new resources, such as chromosome substitution strains and the proposed Collaborative Cross, together with new analytical tools, including probabilistic ancestral haplotype reconstruction in outbred mice, Yin-Yang crosses and in silico analysis of sequence variants in many inbred strains, could make QTL cloning tractable. We review the potential of these strategies to identify genes that underlie QTLs in rodents.

引用

页码：271 / 286

页数：16

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