Wnt/Notch signalling and information processing during development

被引：246

作者：

Hayward, Penelope ^{[1
]}

Kalmar, Tibor ^{[1
]}

Arias, Alfonso Martinez ^{[1
]}

机构：

[1] Univ Cambridge, Dept Genet, Cambridge CB2 3EH, England

来源：

DEVELOPMENT | 2008年 / 135卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

D O I：

10.1242/dev.000505

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Wnt and Notch signalling pathways represent two major channels of communication used by animal cells to control their identities and behaviour during development. A number of reports indicate that their activities are closely intertwined during embryonic development. Here, we review the evidence for this relationship and suggest that Wnt and Notch ('Wntch') signalling act as components of an integrated device that, rather than defining the fate of a cell, determines the probability that a cell will adopt that fate.

引用

页码：411 / 424

页数：14

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