From the cholinergic gene locus to the cholinergic neuron

被引：18

作者：

Weihe, E

Schafer, MKH

Schutz, B

Anlauf, M

Depboylu, C

Brett, C

Chen, LB

Eiden, LE

机构：

[1] Univ Marburg, Dept Anat & Cell Biol, D-35033 Marburg, Germany

[2] NIMH, Mol Neurosci Sect, Lab Cellular & Mol Regulat, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF PHYSIOLOGY-PARIS | 1998年 / 92卷 / 5-6期

关键词：

synaptic vesicle; acetylcholine; VAChT; ChAT; peripheral and central nervous system; ontogeny; cholinergic differentiation;

D O I：

10.1016/S0928-4257(99)80010-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The cholinergic gene locus (CGL) was first identified in 1994 as the site (human chromosome 10q11.2) at which choline acetyltransferase and a functional vesicular acetylcholine transporter are co-localized. Here, we present recent neuroanatomical, developmental, and evolutionary insights into the chemical coding of cholinergic neurotransmission that have been gleaned from the study of the CGL, and its protein products VAChT and ChAT, which comprise a synthesis-sequestration pathway that functionally defines the cholinergic phenotype. ((C) Elsevier, Paris).

引用

页码：385 / 388

页数：4

共 20 条

[1]

AGOSTON DV, 1988, EXP BRAIN RES, V72, P535

[2] ALTERNATIVE SPLICING LEADS TO 2 CHOLINERGIC PROTEINS IN CAENORHABDITIS-ELEGANS [J].