Microwave-enhanced bismuth triflate-catalyzed epoxide opening with aliphatic amines

被引：34

作者：

Ollevier, Thierry ^{[1
]}

Nadeau, Etienne ^{[1
]}

机构：

[1] Univ Laval, Dept Chim, Quebec City, PQ G1K 7P4, Canada

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 09期

基金：

加拿大创新基金会; 加拿大自然科学与工程研究理事会;

关键词：

bismuth; bismuth(III) triflate; epoxide; aliphatic amine; 2-amino alcohol;

D O I：

10.1016/j.tetlet.2007.12.100

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In the presence of a catalytic amount of Bi(OTf)(3)-4H(2)O and under microwave irradiation, neat mixtures of epoxides and amines afforded smoothly the corresponding 2-amino alcohols. A wide variety of aliphatic amines were reacted with cycloalkene oxide, styrene oxide, and stilbene oxide. The reaction proceeded rapidly and afforded the 2-amino alcohols in high up to quantitative yields. All products could be obtained without aqueous work-up by simple filtration. (c) 2007 Published by Elsevier Ltd.

引用

页码：1546 / 1550

页数：5

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