Hydroxy- and alkoxycyclizations of enynes catalyzed by platinum(II) chloride

被引：45

作者：

Muñoz, MP ^{[1
]}

Méndez, M ^{[1
]}

Nevado, C ^{[1
]}

Cárdenas, DJ ^{[1
]}

Echavarren, AM ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Dept Quim Organ, E-28049 Madrid, Spain

来源：

SYNTHESIS-STUTTGART | 2003年 / 18期

关键词：

enynes; platinum; gold; cyclizations; carbenes;

D O I：

10.1055/s-2003-42456

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cyclization of 1-en-6-ynes catalyzed by PtCl2 in the presence of water or alcohols affords five or six-membered ring carbocycles containing hydroxy or alkoxy functional groups in high yields. The alkoxycyclizations can also be performed with AuCl3 as catalyst. The reaction is stereospecific, atom-economical, and takes place in environmentally friendly solvents.

引用

页码：2898 / 2902

页数：5

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