Detection of single magnetic bead for biological applications using an InAs quantum-well micro-Hall sensor -: art. no. 112502

被引：77

作者：

Mihajlovic, G ^{[1
]}

Xiong, P

von Molnár, S

Ohtani, K

Ohno, H

Field, M

Sullivan, GJ

机构：

[1] Florida State Univ, MARTECH, Tallahassee, FL 32306 USA

[2] Florida State Univ, Dept Phys, Tallahassee, FL 32306 USA

[3] Tohoku Univ, Elect Commun Res Inst, Lab Nanoelect & Spintron, Sendai, Miyagi 980, Japan

[4] Rockwell Sci Co LLC, Thousand Oaks, CA 91360 USA

来源：

APPLIED PHYSICS LETTERS | 2005年 / 87卷 / 11期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1063/1.2043238

中图分类号：

O59 [应用物理学];

学科分类号：

摘要：

Room-temperature detection of a single commercial superparamagnetic bead (1.2 mu m in diameter) suitable for biological applications has been realized using an InAs quantum-well micro-Hall sensor. The detection was demonstrated using phase-sensitive detection on a single Hall cross as well as in a Hall gradiometry setup. The high signal to noise ratio, obtained in both configurations, promises detection of single nanometer-size particles by further miniaturization of the device to submicron dimensions. (c) 2005 American Institute of Physics.

引用

页数：3

共 20 条

[1] A biosensor based on magnetoresistance technology [J].

Baselt, DR ;

Lee, GU ;

Natesan, M ;

Metzger, SW ;

Sheehan, PE ;

Colton, RJ .

BIOSENSORS & BIOELECTRONICS, 1998, 13 (7-8) :731-739

[2] Detection of a single magnetic microbead using a miniaturized silicon Hall sensor [J].

Besse, PA ;

Boero, G ;

Demierre, M ;

Pott, V ;

Popovic, R .

APPLIED PHYSICS LETTERS, 2002, 80 (22) :4199-4201

[3] Biological sensors based on Brownian relaxation of magnetic nanoparticles [J].

Chung, SH ;

Hoffmann, A ;

Bader, SD ;

Liu, C ;

Kay, B ;

Makowski, L ;

Chen, L .

APPLIED PHYSICS LETTERS, 2004, 85 (14) :2971-2973

[4] Proposed biosensors based on time-dependent properties of magnetic fluids [J].

Connolly, J ;

St Pierre, TG .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2001, 225 (1-2) :156-160

[5] Response function of a Hall magnetosensor in the diffusive regime [J].

Cornelissens, YG ;

Peeters, FM .

JOURNAL OF APPLIED PHYSICS, 2002, 92 (04) :2006-2012

[6] Planar Hall effect sensor for magnetic micro- and nanobead detection [J].

Ejsing, L ;

Hansen, MF ;

Menon, AK ;

Ferreira, HA ;

Graham, DL ;

Freitas, PP .

APPLIED PHYSICS LETTERS, 2004, 84 (23) :4729-4731

[7] Biodetection using magnetically labeled biomolecules and arrays of spin valve sensors (invited) [J].

Ferreira, HA ;

Graham, DL ;

Freitas, PP ;

Cabral, JMS .

JOURNAL OF APPLIED PHYSICS, 2003, 93 (10) :7281-7286

[8] Single magnetic microsphere placement and detection on-chip using current line designs with integrated spin valve sensors: Biotechnological applications [J].

Graham, DL ;

Ferreira, H ;

Bernardo, J ;

Freitas, PP ;

Cabral, JMS .

JOURNAL OF APPLIED PHYSICS, 2002, 91 (10) :7786-7788

[9] SQUID based remanence measurements for immunoassays [J].

Kotitz, R ;

Matz, H ;

Trahms, L ;

Koch, H ;

Weitschies, W ;

Rheinlander, T ;

Semmler, W ;

Bunte, T .

IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY, 1997, 7 (02) :3678-3681

[10] Characterization of single magnetic particles with InAs quantum-well Hall devices [J].

Landry, G ;

Miller, MM ;

Bennett, BR ;

Johnson, M ;

Smolyaninova, V .

APPLIED PHYSICS LETTERS, 2004, 85 (20) :4693-4695

← 1 2 →