Information networks in the mammary gland

被引:355
作者
Hennighausen, L [1 ]
Robinson, GW [1 ]
机构
[1] NIDDK, Lab Genet & Physiol, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1038/nrm1714
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Unique developmental features during puberty, pregnancy, lactation and post-lactation make the mammary gland a prime object to explore genetic circuits that control the specification, proliferation, differentiation, survival and death of cells. Steroids and simple peptide hormones initiate and carry out complex developmental programmes, and reverse genetics has been used to define the underlying mechanistic connections.
引用
收藏
页码:715 / 725
页数:11
相关论文
共 80 条
[71]  
Wagner KU, 2002, DEVELOPMENT, V129, P1377
[72]   Impaired alveologenesis and maintenance of secretory mammary epithelial cells in Jak2 conditional knockout mice [J].
Wagner, KU ;
Krempler, A ;
Triplett, AA ;
Qi, YY ;
George, NM ;
Zhu, JQ ;
Rui, H .
MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (12) :5510-5520
[73]   MAMMARY-GLAND FACTOR (MGF) IS A NOVEL MEMBER OF THE CYTOKINE REGULATED TRANSCRIPTION FACTOR GENE FAMILY AND CONFERS THE PROLACTIN RESPONSE [J].
WAKAO, H ;
GOUILLEUX, F ;
GRONER, B .
EMBO JOURNAL, 1994, 13 (09) :2182-2191
[74]   Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation [J].
Walton, KD ;
Wagner, KU ;
Rucker, EB ;
Shillingford, JM ;
Miyoshi, K ;
Hennighausen, L .
MECHANISMS OF DEVELOPMENT, 2001, 109 (02) :281-293
[75]  
Wiesen JF, 1999, DEVELOPMENT, V126, P335
[76]   Galanin regulates prolactin release and lactotroph proliferation [J].
Wynick, D ;
Small, CJ ;
Bacon, A ;
Holmes, FE ;
Norman, M ;
Ormandy, CJ ;
Kilic, E ;
Kerr, NCH ;
Ghatei, M ;
Talamantes, F ;
Bloom, SR ;
Pachnis, V .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (21) :12671-12676
[77]   Murine progesterone receptor expression in proliferating mammary epithelial cells during normal pubertal development and adult estrous cycle:: Association with ERα and ERβ status [J].
Zeps, N ;
Bentel, JM ;
Papadimitriou, JM ;
Dawkins, HJS .
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1999, 47 (10) :1323-1330
[78]   Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK [J].
Zhao, L ;
Hart, S ;
Cheng, JG ;
Melenhorst, JJ ;
Bierie, B ;
Ernst, M ;
Stewart, C ;
Schaper, F ;
Heinrich, PC ;
Ullrich, A ;
Robinson, GW ;
Hennighausen, L .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (42) :44093-44100
[79]   Loss of interleukin 6 results in delayed mammary gland involution: A possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3 [J].
Zhao, L ;
Melenhorst, JJ ;
Hennighausen, L .
MOLECULAR ENDOCRINOLOGY, 2002, 16 (12) :2902-2912
[80]   Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation [J].
Zhou, J ;
Chehab, R ;
Tkalcevic, J ;
Naylor, MJ ;
Harris, J ;
Wilson, TJ ;
Tsao, S ;
Tellis, I ;
Zavarsek, S ;
Xu, DK ;
Lapinskas, EJ ;
Visvader, J ;
Lindeman, GJ ;
Thomas, R ;
Ormandy, CJ ;
Hertzog, PJ ;
Kola, I ;
Pritchard, MA .
EMBO JOURNAL, 2005, 24 (03) :635-644