Neuropsychiatric symptoms in patients with multiple sclerosis

被引：72

作者：

Figved, N

Klevan, G

Myhr, KM

Glad, S

Nyland, H

Larsen, JP

Harboe, E

Omdal, R

Aarsland, D

机构：

[1] Stavanger Univ Hosp, Ctr Clin Neurosci, Sect Geriatr Psychiat, N-4095 Stavanger, Norway

[2] Stavanger Univ Hosp, Dept Neurol, N-4095 Stavanger, Norway

[3] Haukeland Hosp, Dept Neurol, N-5021 Bergen, Norway

[4] Stavanger Univ Hosp, Ctr Clin Neurosci Res, Stavanger, Norway

[5] Sch Med, Bergen, Norway

[6] Stavanger Univ Hosp, Dept Internal Med, Stavanger, Norway

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2005年 / 112卷 / 06期

关键词：

multiple sclerosis; neuropsychiatric symptoms; the neuropsychiatric inventory; depression;

D O I：

10.1111/j.1600-0447.2005.00624.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objective: To explore the range of psychiatric symptoms in patients with multiple sclerosis (MS) and their association with neurological disability. Method: Patients diagnosed with MS during 1998-2000 in Rogaland and Hordaland counties, western Norway, were included. Psychiatric symptoms were assessed by the Neuropsychiatric Inventory (NPI). Patients with systemic lupus erythematosus (SLE) served as controls. Results: Eighty-six of 93 eligible MS patients were included, and 80% showed at least one psychiatric symptom. The most frequent symptoms were depression (59%), sleep disturbance (48%), irritability/emotional lability (42%), and apathy (31%). Depression was associated with higher disability score. MS patients showed significantly higher NPI irritability score (P = 0.002), appetite disturbance score (P < 0.001), and apathy score (P = 0.01) than SLE patients. Conclusion: Neuropsychiatric symptoms occur frequently in patients with MS. Irritability and apathy are independent of disability and chronic disease and represent unique disease manifestations.

引用

页码：463 / 468

页数：6

共 35 条

[1] Personality disorder in multiple sclerosis correlates with cognitive impairment [J].