Facile Two-Step Synthesis of Porous Antigen-Loaded Degradable Polyelectrolyte Microspheres

被引：40

作者：

Dierendonck, Marijke ^{[1
]}

De Koker, Stefaan ^{[1
,3
]}

Cuvelier, Claude ^{[2
]}

Grooten, Johan ^{[3
]}

Vervaet, Chris ^{[1
]}

Remon, Jean-Paul ^{[1
]}

De Geest, Bruno G. ^{[1
]}

机构：

[1] Univ Ghent, Pharmaceut Technol Lab, Dept Pharmaceut, B-9000 Ghent, Belgium

[2] Univ Ghent, Dept Pathol, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Biomed Mol Biol, Lab Mol Immunol, B-9000 Ghent, Belgium

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 46期

关键词：

antigens; drug delivery; microporous materials; nanotechnology; polymers; MULTILAYER CAPSULES; MICROCAPSULES; DELIVERY; PARTICLES; ENCAPSULATION; RELEASE; SPHERES; SYSTEM; FILMS; DNA;

D O I：

10.1002/anie.201001046

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Pore medicine: Porous antigen-loaded degradable polyelectrolyte microspheres are produced in a straightforward way providing high encapsulation efficiencies and efficient internalization by antigen-presenting cells. This system could find application as multilayer capsules in gene and drug delivery and for enzymatic microreactors. © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

收藏

页码：8620 / 8624

页数：5

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