Simplified dynemicin analogues: diastereoselective synthesis and evaluation of their activity against plasmid DNA

被引：16

作者：

Guanti, G ^{[1
]}

Riva, R ^{[1
]}

机构：

[1] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2003年 / 1卷 / 22期

关键词：

D O I：

10.1039/b307966j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The total synthesis of two diastereoisomeric simplified dynemicin analogues is reported. The key steps involved are: the regio- and diastereoselective functionalisation of an appropriate racemic quinoline precursor and the ring closure to give the 10-membered enediyne moiety through a Pd(0)-catalysed Stille reaction. After the successful conversion of one of these derivatives into a compound more readily activable under nearly physiological conditions, the activity against plasmid DNA was evaluated.

引用

页码：3967 / 3976

页数：10

共 48 条

[1]

Banfi L, 2002, EUR J ORG CHEM, V2002, P3745, DOI 10.1002/1099-0690(200211)2002:22<3745::AID-EJOC3745>3.0.CO

[2]

2-C

[3]

Banfi L, 1998, EUR J ORG CHEM, V1998, P1543

[4]

Banfi L, 2000, EUR J ORG CHEM, V2000, P939