LACTENDIYNES - A NEW CLASS OF TRIGGERED CYCLIC ENEDIYNES

被引：60

作者：

BANFI, L ^{[1
]}

GUANTI, G ^{[1
]}

机构：

[1] CNR,IST CHIM ORGAN,CTR STUDIO CHIM COMPOSTI CICLOALIFATICI & AROMAT,I-16132 GENOA,ITALY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 21期

关键词：

ANTITUMOR AGENTS; AZETIDINONES; CYCLOAROMATIZATIONS; ENEDIYNES;

D O I：

10.1002/anie.199523931

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A promising prodrug, the stable cyclic enediyne 1, unleashes a reactive, potentially DNA‐damaging enediyne when the β‐lactam group is hydrolyzed under basic conditions. This intermediate rapidly undergoes cycloaromatization giving a phenylene diradical, which can be trapped by 1,4‐cyclohexadiene. R1, R2  OMe, H. (Figure Presented.) Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：2393 / 2395

页数：3

共 19 条

[1] AN EFFICIENT PALLADIUM-CATALYZED REACTION OF VINYL CHLORIDES WITH TERMINAL ACETYLENES
ALAMI, M
LINSTRUMELLE, G
[J]. TETRAHEDRON LETTERS, 1991, 32 (43) : 6109 - 6112
[2] BANFI L, 1994, SEMINARS ORGANIC SYN, P253
[3] SYNTHESIS AND OXIDATIVE ACTIVATION OF AN OXABICYCLO[7.2.1] ENEDIYNE
BRANDSTETTER, T
MAIER, ME
[J]. TETRAHEDRON, 1994, 50 (05) : 1435 - 1448
[4] PALLADIUM-CATALYZED REACTION OF (E)-DICHLOROETHENE AND (Z)-DICHLOROETHENE WITH 1-ALKYNES - AN EFFICIENT STEREOSPECIFIC SYNTHESIS OF (E)-ENEDIYNES AND (Z)-ENEDIYNES
CHEMIN, D
LINSTRUMELLE, G
[J]. TETRAHEDRON, 1994, 50 (18) : 5335 - 5344
[5] THE ESPERAMICIN-CALICHEAMICIN AGLYCONES - RING-CLOSURE OF A SIMPLE STRAINED SYSTEM MEDIATED BY CHROMIUM(II)-NICKEL(II) SALTS
CREVISY, C
BEAU, JM
[J]. TETRAHEDRON LETTERS, 1991, 32 (27) : 3171 - 3174
[6] MAIER ME, 1995, SYNLETT, P13
[7] DESIGNED ENEDIYNES - A NEW CLASS OF DNA-CLEAVING MOLECULES WITH POTENT AND SELECTIVE ANTICANCER ACTIVITY
NICOLAOU, KC
DAI, WM
TSAY, SC
ESTEVEZ, VA
WRASIDLO, W
[J]. SCIENCE, 1992, 256 (5060) : 1172 - 1178
[8] CYCLIC CONJUGATED ENEDIYNES RELATED TO CALICHEAMICINS AND ESPERAMICINS - CALCULATIONS, SYNTHESIS, AND PROPERTIES
NICOLAOU, KC
ZUCCARELLO, G
OGAWA, Y
SCHWEIGER, EJ
KUMAZAWA, T
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (14) : 4866 - 4868
[9] 10-MEMBERED RING ENEDIYNES WITH REMARKABLE CHEMICAL AND BIOLOGICAL PROFILES
NICOLAOU, KC
SORENSEN, EJ
DISCORDIA, R
HWANG, CK
MINTO, RE
BHARUCHA, KN
BERGMAN, RG
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1992, 31 (08): : 1044 - 1046
[10] CHEMISTRY AND BIOLOGY OF NATURAL AND DESIGNED ENEDIYNES
NICOLAOU, KC
SMITH, AL
YUE, EW
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) : 5881 - 5888

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