Synthesis of deuterium-labelled 2,5-bis(4-amidinophenyl)furan, 2,5-bis[4-(methoxyamidino)phenyl]furan, and 2,7-diamidinocarbazole

被引:17
作者
Stephens, CE [1 ]
Patrick, DA
Chen, HD
Tidwell, RR
Boykin, DW
机构
[1] Georgia State Univ, Dept Chem, Atlanta, GA 30303 USA
[2] Univ N Carolina, Sch Med, Dept Pathol & Lab Med, Chapel Hill, NC 27599 USA
关键词
deuterium-labelled; 2,5-bis(4-amidinophenyl)furan-d(8); 2,5-bis[4-(methoxyamidino)phenyl]furan-d(8); 2,7-diamidinocarbazole-d(6); antimicrobial; prodrug;
D O I
10.1002/jlcr.444
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The syntheses of 2,5-bis(4-amidinophenyl)furan-d(8) (1-d(8)) and 2,5-bis[4-(methoxyamidino)phenyl]furan-d(8) (2-d(8)) from bromobenzene-d(5) in six steps, and of 2,7-diamidinocarbazole-d(6) (3-d(6)) from biphenyl-d(10) in five steps, are described.
引用
收藏
页码:197 / 208
页数:12
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