Anti-pneumocystis activity of bis-amidoximes and bis-O-alkylamidoximes prodrugs

被引：99

作者：

Boykin, DW

Kumar, A

Hall, JE

Bender, BC

Tidwell, RR

机构：

[1] GEORGIA STATE UNIV,CTR BIOTECHNOL & DRUG DESIGN,ATLANTA,GA 30303

[2] UNIV N CAROLINA,DEPT EPIDEMIOL,CHAPEL HILL,NC 27599

[3] UNIV N CAROLINA,DEPT PATHOL,CHAPEL HILL,NC 27599

[4] UNIV N CAROLINA,DEPT MED CHEM,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 24期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(96)00557-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the synthesis of 2,5-bis-[4-amidinophenyl]furan bis-amidoxime(2), the corresponding bis-O-methylamidoxime(3) and the corresponding bis-O-ethylamidoxime(4) and their evaluation as prodrugs against Pneumocystis carinii pneumonia. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：3017 / 3020

页数：4

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