DNA biosensors and microarrays

被引：1003

作者：

Sassolas, Audrey ^{[1
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Leca-Bouvier, Beatrice D. ^{[1
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,3
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Blum, Loic J. ^{[1
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,6
]}

机构：

[1] Inst Chim & Biochim Mol & Supramol, Lab Genie Enzymat & Biomol, 43 Blvd 11 Novembre 1918, F-69622 Villeurbanne, France

[2] Univ Lyon, F-69622 Villeurbanne, France

[3] CNRS, UMR5246, F-69622 Villeurbanne, France

[4] Univ Lyon 1, F-69622 Villeurbanne, France

[5] Inst Natl Sci Appl, Ecole Ingn, F-69621 Villeurbanne, France

[6] Ecole Super Chim Phys Elect Lyon, F-69616 Villeurbanne, France

来源：

CHEMICAL REVIEWS | 2008年 / 108卷 / 01期

关键词：

D O I：

10.1021/cr0684467

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A review regarding the recent development of DNA biosensors and microarrays is given. Aside from the usual discussion on electrochemical transduction, this review further describes the optical and piezoelectric transduction modes. In addition, the recent evolution of DNA microarrays as well as the DNA probe immobilization and hybridization detection has been reported. Several DNA detection systems that is based on the hybridization between a DNA target and its complementary probe have been described. There are two aspects to be considered when developing such hybridization biosensors and microarrays. These are the sensitivity and the selectivity. Specific topics discussed include DNA immobilization and the nucleic acid hybridization detection.

引用

页码：109 / 139

页数：31

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