Porosity-graded hydroxyapatite ceramics to replace natural bone

被引：235

作者：

Tampieri, A

Celotti, G

Sprio, S

Delcogliano, A

Franzese, S

机构：

[1] CNR, IRTEC, I-48018 Faenza, RA, Italy

[2] Univ Cattolica Sacro Cuore, Clin Ortoped, Policlin Gemelli, I-00168 Rome, Italy

来源：

BIOMATERIALS | 2001年 / 22卷 / 11期

关键词：

hydroxyapatite; porous ceramic; porosity gradient; bone tissue mimicking;

D O I：

10.1016/S0142-9612(00)00290-8

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Porous hydroxyapatite HA bodies were prepared with an aim to simulate bone tissue morphology. By varying the characteristics of starting L-IA powders and the impregnation strategy of cellulosic sponges with theologically optimized slurries, a wide range of physico-chemical and mechanical properties of the porous ceramics can be obtained. The samples were characterized microstructurally, by density and porosimetry and by mechanical strength. Cylindrical specimens exhibiting a porosity gradient showed a promising behaviour after implantation in rabbits' femur: newly formed bone grew in tight contact with the ceramic in a very short time, no modified cells are induced and bone tissue fills even the inner pores. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1365 / 1370

页数：6

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